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慢性疲劳应激对大鼠伏隔核一氧化氮合酶表达的影响
引用本文:刘鸿宇,杨桂姣,崔建梅,宋晓霞. 慢性疲劳应激对大鼠伏隔核一氧化氮合酶表达的影响[J]. 解剖学杂志, 2008, 31(4)
作者姓名:刘鸿宇  杨桂姣  崔建梅  宋晓霞
作者单位:中北大学生理学实验室,太原,030051;山西医科大学人体解剖学教研室,太原,030001
基金项目:中北大学校科研和教改项目
摘    要:目的:探讨长时间游泳引起的疲劳应激对大鼠伏隔核(NAc)中神经元型一氧化氮合酶(nNOS)表达的影响.方法:采用成年雄性大鼠连续4周每天强迫游泳至力竭,用免疫组织化学方法结合图像处理测定伏隔核中nNOS的表达.结果:长时间强迫游泳应激可使大鼠伏隔核巾nNOS免疫细胞化学反应阳性神经元的数量(106.7%)、面积(150.2%)和灰度值(11.3%)显著增加.结论:nNOS参与疲劳应激的形成,一氧化氮在伏隔核对应激调节中起重要作用.

关 键 词:疲劳应激  神经元型一氧化氮合酶  伏隔核

Effects of chronic fatigue on the expression of nitric oxide synthase in rat nucleus accumbens
Liu Hongyu,Yang Guijiao,Cui Jianmei,Song Xiaoxia. Effects of chronic fatigue on the expression of nitric oxide synthase in rat nucleus accumbens[J]. Chinese Journal of Anatomy, 2008, 31(4)
Authors:Liu Hongyu  Yang Guijiao  Cui Jianmei  Song Xiaoxia
Abstract:Objective: To assess the effects of chronic fatigue induced by swimming on the expression of neuronal nitric oxide synthase(nNOS) in the rat nucleus accumbens.Methods: Adult male Wistar rats were forced to swim till exhaustion every day for 4 weeks.Immunohistochemistry combined with the image manipulation was used for the measurement of nNOS positive neurons.Results: A long-time exposure to chronic forced swimming significantly increased the number(106.7%),distributed area(150.2%) and gray degree(11.3%) of nNOS immunoreactive positive neurons in the nucleus accumbens.Conclusion: nNOS might be involved in the formation of fatigue stress,and that nitric oxide(NO) might play an important role in the regulation of stress in the nucleus accumbens.
Keywords:fatigue stress  neuronal nitric oxide synthase  nucleus accumbens
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