| Institution: | 1. Institute for Medical Technology Assessment, Erasmus University Rotterdam, the Netherlands;2. Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands;3. Novartis Pharma B.V., Arnhem, the Netherlands;4. Department of Cardiology, Hospital Group Twente, Almelo and Hengelo, the Netherlands;5. Department of Cardiology, VieCuri Medical Centre Noord-Limburg, Venlo, the Netherlands;6. Institute of Health Care Policy and Management, Erasmus University Rotterdam, Rotterdam, the Netherlands |
| Abstract: | ObjectivesTo describe the adaptation of a global health economic model to determine whether treatment with the angiotensin receptor neprilysin inhibitor LCZ696 is cost effective compared with the angiotensin-converting enzyme inhibitor enalapril in adult patients with chronic heart failure with reduced left ventricular ejection fraction in the Netherlands; and to explore the effect of performing the cost-effectiveness analyses according to the new pharmacoeconomic Dutch guidelines (updated during the submission process of LCZ696), which require a value-of-information analysis and the inclusion of indirect medical costs of life-years gained.MethodsWe adapted a UK model to reflect the societal perspective in the Netherlands by including travel expenses, productivity loss, informal care costs, and indirect medical costs during the life-years gained and performed a preliminary value-of-information analysis.ResultsThe incremental cost-effectiveness ratio obtained was €17,600 per quality-adjusted life-year (QALY) gained. This was robust to changes in most structural assumptions and across different subgroups of patients. Probability sensitivity analysis results showed that the probability that LCZ696 is cost-effective at a €50,000 per QALY threshold is 99.8%, with a population expected value of perfect information of €297,128. On including indirect medical costs of life-years gained, the incremental cost-effectiveness ratio was €26,491 per QALY gained, and LCZ696 was 99.46% cost effective at €50,000 per QALY, with a population expected value of perfect information of €2,849,647.ConclusionsLCZ696 is cost effective compared with enalapril under the former and current Dutch guidelines. However, the (monetary) consequences of making a wrong decision were considerably different in both scenarios. |
