Chemokine/chemokine receptor interactions in extramedullary leukaemia of the skin in childhood AML: Differential roles for CCR2, CCR5, CXCR4 and CXCR7 |
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| Authors: | Claudia MJM Faaij MSc Annemieke J Willemze PhD MD Tom Révész PhD MD Melania Balzarolo MSc Cornelis P Tensen PhD Manja Hoogeboom BSc Maarten H Vermeer PhD MD Elisabeth van Wering PhD Christian M Zwaan PhD MD Gertjan JL Kaspers PhD MD Colin Story MSc Astrid GS van Halteren PhD Jaak M Vossen PhD MD R Maarten Egeler PhD MD Maarten JD van Tol PhD Nicola E Annels PhD |
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| Institution: | 1. Division of Immunology, Haematology, Oncology, Bone Marrow Transplantation and Autoimmune Diseases, Department of Paediatrics, Leiden University Medical Centre, Leiden, the Netherlands;2. Department of Haematology/Oncology, Women's & Children's Hospital, Adelaide, South Australia, Australia;3. Department of Dermatology, Leiden University Medical Centre, Leiden, the Netherlands;4. The Dutch Childhood Oncology Group (DCOG), The Hague, the Netherlands;5. Paediatric Oncology/Haematology, Erasmus MC/Sophia Children's Hospital, Rotterdam, the Netherlands;6. Paediatric Oncology/Haematology, VU University Medical Centre, Amsterdam, the Netherlands |
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| Abstract: | Chemokine receptor/ligand interactions orchestrate the migration of cells to peripheral tissues such as the skin. We analysed chemokine receptor expression by acute myeloid leukaemic (AML) cells present in peripheral blood (n = 7), bone marrow (n = 6), or skin (n = 11) obtained from 15 paediatric AML patients with skin involvement and in 10 AML patients without skin involvement. High percentages of circulating CCR2pos AML cells were only detected in patients with extramedullary disease. Skin‐residing AML cells displayed a different set of receptors in situ, namely: CCR5, CXCR4, CXCR7 and CX3CR1. These results suggest the involvement of different chemokine/chemokine receptor interactions in homing and retention of AML blasts in the skin. Pediatr Blood Cancer. 2010;55:344–348. © 2010 Wiley–Liss, Inc. |
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| Keywords: | AML chemokines paediatric haematology/oncology |
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