The Use of the Woodchuck as an Animal Model for Evaluation of Transarterial Embolization |
| |
| Authors: | Luke R Wilkins James R Stone Jaime Mata Alisha Hawrylack Ewa Kubicka David L Brautigan |
| |
| Institution: | 1. Department of Radiology and Medical Imaging, University of Virginia Health Systems, Charlottesville, Virginia;2. Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia |
| |
| Abstract: | There are many shortcomings of current animal models as surrogates of hepatocellular carcinoma that handicap preclinical testing of embolization agents. The present study explores the feasibility of using the woodchuck (Marmota monax) as an animal model for the testing of novel embolization agents. Four woodchucks underwent magnetic resonance imaging, angiography, and left lobar hepatic artery particle embolization. Percutaneous access, arteriography, and lobar embolization were successful in all animals, with angiographic stasis obtained in the target vessel with minimal reflux of embolic material. These results support the feasibility of the woodchuck as an animal model for preclinical testing of embolization agents. |
| |
| Keywords: | FOV field of view HASTE half-Fourier acquisition single-shot turbo spin-echo HCC hepatocellular carcinoma PVA polyvinyl alcohol TE echo time TR repetition time WHV woodchuck hepatitis virus |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
