Apoptotic‐related protein changes induced by hexavalent chromium in mice liver |
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| Authors: | Xiao‐Feng Wang Xiao‐Ming Lou Ying Shen Ming‐Luan Xing Li‐Hong Xu |
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| Institution: | 1. Zhejiang Center for Disease Control and Prevention, Hangzhou 310051, China;2. Department of Biochemistry and Genetics, School of Medicine, Zhejiang University, Hangzhou 310058, China;3. Department of Neonatology, Children's Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China |
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| Abstract: | Although it has been reported that hexavalent chromium (Cr(VI)) could induce apoptosis in a variety of cell types, the molecular mechanisms underlying this process is still largely unknown. This study was undertaken to determine effects of single oral 0, 25, 50, and 100 mg/kg body weight doses of potassium dichromate on the expression level of p53, Bcl‐2, Bax, cytochrome c, and caspase‐3, which are vital regulators of apoptosis, in mice liver. The results showed that Cr(VI) could upregulate the protein expression of p53, Bax, cytochrome c, and caspase‐3 and downregulate the expression of Bcl‐2 in mice liver. All these results suggested that p53, Bcl‐2, Bax, cytochrome c, and caspase‐3 may be involved in the regulation of Cr(VI) induced apoptosis in vivo. © 2009 Wiley Periodicals, Inc. Environ Toxicol, 2010. |
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| Keywords: | Cr(VI) apoptosis p53 Bcl‐2 Bax cytochrome c caspase‐3 in vivo |
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