Abdominal undifferentiated small round cell tumor with unique translocation (X;19)(q13;q13.3) |
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| Authors: | Jason T. Yustein MD PhD Surya Rednam MD Alison A. Bertuch MD PhD John A. Goss MD Mary L. Brandt MD Karen Eldin MD Xinyan Lu PhD John Hicks MD PhD DDS |
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| Affiliation: | 1. Department of Pediatrics, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas;2. Department of Surgery, Division of Abdominal Transplantation and Hepatobiliary Surgery, Baylor College of Medicine, Houston, Texas;3. Michael E. DeBakey Department of Surgery, Division of Pediatric Surgery, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas;4. Department of Pathology, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas;5. Clinical Cytogenetics Molecular Laboratory, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas |
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| Abstract: | We describe a male with a large abdominal mass, most likely originating from the liver, with capsule rupture and tumor dissemination into the abdominal cavity. Adherence of the tumor to the diaphragm and lower right colon also were noted. A comprehensive evaluation of the mass revealed no tumor‐defining histopathologic, immunocytochemical, ultrastructural, cytogenetic, or translocation features. The malignant tumor was found to have a novel translocation (X;19)(q13;13.3), which has not been reported in small round cell tumors of childhood or adults. The final diagnosis rendered was an undifferentiated small round cell tumor of uncertain cell of origin. Pediatr Blood Cancer 2010;54:1041–1044 © 2010 Wiley‐Liss, Inc. |
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| Keywords: | novel translocation undifferentiated small round cell tumor |
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