Glucagon for refractory asthma exacerbation |
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Authors: | Jillian M. Cavallari Tara S. Jawaro Nadia I. Awad Patrick J. Bridgeman |
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Affiliation: | 1. Department of Pharmacy, Robert Wood Johnson University Hospital, New Brunswick, NJ;2. Department of Pharmacy Practice and Administration, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ |
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Abstract: | Glucagon, a hormone secreted by pancreatic alpha cells, causes bronchial smooth muscle relaxation by activating the synthesis of cyclic adenosine monophosphate. It was studied in the 1980s and 1990s as a treatment option for the management of asthma but has since not been evaluated. Data to support its use are limited, but it may serve as a last-line agent for refractory asthma exacerbation. Here we describe 4 cases in which intravenous glucagon was used to manage severe, refractory asthma exacerbation in the emergency department. |
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Keywords: | Corresponding author at: Emergency Medicine Pharmacist Robert Wood Johnson University Hospital 1 Robert Wood Johnson Pl New Brunswick NJ 08901. |
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