Antiplasmodial activities of furoquinoline alkaloids from Teclea afzelii |
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| Authors: | Jean Duplex Wansi Hidayat Hussain Alain Tadjong Tcho Simeon F. Kouam Sabine Specht Salem Ramadan Sarite Achim Hoerauf Karsten Krohn |
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| Affiliation: | 1. Department of Chemistry, University of Douala, Faculty of Science, P.O. Box 24157, Douala, Cameroon;2. Department of Chemistry, Universit?t Paderborn, Warburger Stra?e 100, 33098 Paderborn, Germany;3. Department of Chemistry, Higher Teachers' Training College, University of Yaounde 1, BP 47, Yaounde, Cameroon;4. Institute of Medical Parasitology, University of Bonn, Sigmund Freud Str. 25, 53105 Bonn, Germany |
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| Abstract: | The study of the chemical constituents of the stem bark of Teclea afzelii (Rutaceae) has resulted in the isolation and characterization of four furoquinoline alkaloids, namely kokusaginine (1), tecleaverdoornine (2), maculine (3) and montrifoline (4) together with lupeol (5) and b‐sitosterol glucopyranoside (6). The structures of the isolated compounds were elucidated based on spectroscopic studies. The antimalarial activity of compounds 1–4 against Plasmodium falciparum in vitro shows partial suppression of parasitic growth. Copyright © 2009 John Wiley & Sons, Ltd. |
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| Keywords: | furoquinoline alkaloids Teclea afzelii antiplasmodial activity |
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