Malignant insulinoma in a child

Insulinomas are rare tumors with an estimated incidence of one per 250,000 person‐years. Most insulinomas are benign with less than 10% demonstrating malignant behavior, the vast majority of which occur in adults. A systemic review of the literature revealed only nine cases of malignant insulinomas occurring in children. Herein, we present a case of metastatic malignant insulinoma in a 12‐year‐old child. The occurrence of this diagnosis in a child, its unusual pattern of metastases and the challenging management of severe hypoglycemia make this case worth reporting. Pediatr Blood Cancer. 2010;55:1423–1426. © 2010 Wiley‐Liss, Inc.