复方丹参滴丸应用于稳定型心绞痛的疗效观察及对CRP和BNP的影响

目的:观察复方丹参滴丸治疗稳定型心绞痛临床疗效,及对CRP(C反应蛋白)和BNP(脑钠肽)的影响。方法:随机选取2011年2月至2016年6月,于我院心内科门诊和住院部就诊的心绞痛患者100例,随机数字表法分为观察组和对照组,每组50例。观察组:口服复方丹参滴丸;对照组:口服单硝酸异山梨酯缓释片。观察并记录2组患者心绞痛发作的次数和每次的持续时间,并采用酶联免疫吸附试验(ELISA)检测分析CRP和BNP。结果:2组稳定型心绞痛心绞痛发作情况均较治疗前有所减轻(P0.05),其中观察组心绞痛发作频次和疼痛持续时间均较对照组少(P0.05)。观察组总有效率优于对照组(P0.05)。血液流变学中,治疗后2组TC、LDL均比治疗前降低(P0.05),而HDL均较治疗前升高(P0.05)。观察组TC、LDL较对照组低(P0.05),HDL高于对照组(P0.05)。2组治疗后CRP、BNP均低于治疗前(P0.05),且观察组比对照组下降的更多(P0.05)。结论:复方丹参滴丸能有效治疗稳定型心绞痛症状,且应用于稳定型心绞痛时能够下调CRP和BNP的表达水平,机制可能与其调控生物因子水平而发挥改善心绞痛的作用有关。

Observation on the Effect of Compound Danshen Dripping Pill on the Treatment for Stable Angina Pectoris and the Effect on CRP and BNP

To observe the clinical effect of Compound Danshen dripping pill in the treatment to stable angina pectoris, and its effect on CRP (C reactive protein) and BNP (brain natriuretic peptide). Methods:A total of 100 cases of angina pectoris in our hospital from June -2016, February 2011, were randomly divided into the observation group and the control group, with 50 cases in each group. Observation group: oral compound Danshen dripping pills; control group: oral Isosorbide Mononitrate Sustained Release Tablets. The frequency and duration of angina attack were observed and recorded in two groups, and the CRP and BNP were detected by enzyme-linked immunosorbent assay (ELISA).Results:While angina pectoris attacked, both groups of patients'' conditions were better than before the treatment. (P<0.05), and for the observation group, the frequency and duration of pain in angina attacking were less than the control group (P<0.05). The total effective rate of the observation group was better than that of the control group (P<0.05). Inhemorheology, the two groups of Tc and LDL were lower than before the treatment (P<0.05), while HDL were higher at the same time(P<0.05). Comparing TC and LDL of the observation group with TC and LDL of control group, the observation group''s were lesser(P<0.05). However, for HDL, observation group was higher than the control group (P<0.05). The two groups after treatment, BNP and CRP were lower than before the treatment (P<0.05), and the observation group decreased more than the control group(P<0.05). Conclusion:Compound Danshen dripping pill is effective in the treatment of stable angina pectoris symptom, and the application in stable angina pectoris can down regulate the expression level of CRP and BNP. The mechanism may be related to the regulation of Compound Danshen dripping pill for biological factors and then play a role in improving the effect of angina pectoris.