急性缺血性中风证候要素演变规律与ASPECTS影像特征的相关性研究

目的:探讨急性缺血性中风证候要素演变规律,并分析头颅影像学特征与证候演变的相关性。方法:从多中心、前瞻性、随机对照临床研究数据库中,选取120例符合纳入标准的发病24 h以内急性缺血性中风病例,通过ASPECTS评分方法对头颅磁共振图像进行评估,采用多因素Logistic回归分析方法,探索基于ASPECTS影像学特征与证候要素演变的相关性。结果:脑缺血损伤主要累及ASPECTS区域中的额顶叶皮层M5(55.0%),内囊(40.9%)和豆状核(30.8%);与发病7 d内证候演变有显著相关性的部位包括尾状核、内囊,以及岛叶、M1、M5、M6等皮层结构(P0.05)。结论:基于ASPECTS的影像特征是影响中风病证候演变的重要因素。

Correlation Study on Evolution of TCM Syndrome Elements and ASPECTS-based Ischemic Characteristic in Patients with Acute Ischemic Stroke

To investigate the evolvement rules of TCM syndrome elements, and to analyze the correlations between neuroimaging characteristic and evolution of TCM syndrome elements. Methods:of acute ischemic stroke was used. A total of 120 patients attacked by acute ischemic stroke within 24 hour were selected from a polycentric and prospective randomized controlled trials database in this study. Magnetic resonance images were assessed via Alberta Stroke Program Early CT score(ASPECTS) method. The correlations between neuroimaging characteristic and evolution of TCM syndrome elements were analyzed according to Logistic analysis.Results:The main ischemic regions of ASPECTS included M5 (55.0%), internal capsule (40.9%), lenticular nucleus(30.8%). Caudate, internal capsule, insular ribbon, as well as cortex of M1, M5 and M6 (P<0.05) were significantly correlated to evolution of TCM syndrome elements within a week of the Stroke attack. Conclusion:ASPECTS-based neuroimaging characteristic is an important factor for evolution of TCM syndrome elements.