针刺联合更年补肾祛瘀汤治疗绝经过渡期肝肾阴虚证的疗效

目的:探讨针刺配合更年补肾祛瘀汤治疗绝经过渡期肝肾阴虚证的临床疗效。方法:选取160例绝经过渡期肝肾阴虚型证患者作为研究对象,给予针刺联合更年补肾祛瘀汤(自拟方)连续治疗12周,比较患者治疗前、后血清雌二醇(E_2)、孕酮(P)、促卵泡激素(FSH)及促黄体生成素(LH)水平的变化,同时采用国内改良Kupperman法评估其临床疗效。结果:治疗后患者血清E_2和P水平均有所升高,血清FSH和LH水平均明显降低,与治疗前比较差异均有统计学意义(P0.05);治疗后患者Kupperman评分(11.58±5.64)分,明显优于治疗前的(33.18±9.76)分,差异有统计学意义(P0.01),总体治疗有效率高达96.25%。结论:针刺配合更年补肾祛瘀汤治疗绝经过渡期肝肾阴虚证的疗效显著,可以有效避免外源性激素引起的不良反应及依赖性。

Therapeutic Effect of Acupuncture Combined with Gengnian Quyu Decoction in the Treatment of Liver-kidney Yin Deficiency During the Menopausal Transitional Period

To investigate the clinical effects of acupuncture combined with Gengnian Quyu Decoction on Liver-Kidney Yin deficiency in patients during the transitional period of menopause.Methods:One hundred and sixty patients with Liver-Kidney Yin deficiency during their menopausal transition were treated with acupuncture combined with Gengnian Quyu Decoction (specific recipe) for 12 weeks. The clinical effects were compared by modified Kupperman grading scale, as well as the levels of serum E2,P,FSH and LH before and after treatment.Results:Significant differences were observed in the serum levels of E2,P,FSH and LH before and after treatment(P<0.01).Kupperman grading scores of(33.18±9.76) and (11.58±5.64) were recorded in patients before and after treatment, respectively (P<0.01).The rate of therapeutic efficiency of this treatment was 96.25%.Conclusion:Significant therapeutic effect was observed when combined acupuncture-Gengnian Quyu Decoction treatment was administered in menopausal transition patients with Liver-Kidney Yin deficiency.The very high efficacy of this treatment makes it a promising regimen.