穴位贴敷联合风咳汤治疗感染后咳嗽的临床研究

目的:探究风咳汤联合穴位贴敷治疗感染后咳嗽的临床疗效,以期丰富治疗方法,为治疗感染后咳嗽提供科学依据。方法:选取2017年1月至2018年1月南京市中西医结合医院收治的感染后咳嗽患者88例作为研究对象,按照随机数字表法随机分为对照组和观察组,每组44例。对照组予常规治疗,观察组在对照组基础上加用风咳汤联合穴位贴敷治疗,均治疗2周。观察比较2组患者采用不同方法治疗前、后中医证候积分、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)、诱导痰上清液中P物质(SP)含量水平变化情况。治疗过程中收集不良反应资料,结束治疗后比较2组疗效。结果:1)2组患者完成治疗方案后,中医症候积分较治疗前均显著下降,观察组显著优于对照组,差异有统计学意义(P<0.05);2)治疗后2组患者IL-8、TNF-α、SP含量均较治疗前显著下降,且观察组优于对照组,差异有统计学意义(P<0.05);3)观察组患者临床控制率、总有效率明显高于对照组,差异有统计学意义(P<0.05)。4)2组患者ALT、AST、CCr、BUN水平和不良反应发生率比较,差异无统计学意义(P>0.05)。结论:风咳汤联合穴位贴敷治疗感染后咳嗽能提高疗效,降低炎性反应水平,改善症状和生命质量。

Clinical Study of Wind Cough Decoction Combined with Acupoint Application in Treating Cough After Infection

Objective:To explore the curative effects of Fengke Decoction combined with Acupoint Application on post-infection cough,so as to enrich the treatment methods and provide a strong basis for the treatment of post-infection cough.Methods:A total of 88 patients with postinfectious cough were enrolled in Nanjing Integrated Traditional Chinese and Western Hospital from January 2017 to January 2018.The patients were divided into a control group(44 cases)and an experimental group(n=44 cases)according to random number table.The control group was given routine treatment,and the experimental group was given Fengke Decoction combined with Acupoint Application on the basis of the control group for 2 weeks.TCM syndrome scores before and after treatment with different methods,and the interleukin-8(IL-8),tumor necrosis factor-α(TNF-α),the level of substance P(SP)in induced sputum supernatant were observed and the adverse reactions were collected during treatment.The efficacy was observed after treatment.Results:1)After completing the treatment regimen in the 2 groups,the TCM symptom scores were significantly lower than those before the treatment,and the observation group was significantly better than that of the the control group(P<0.05);2)the levels of IL-8,TNF-α,and SP in the 2 groups of patients were significantly lower than those tbefore treatment,and the observation group was better than the control group(P<0.05);3)The clinical control rate and total effective rate of the patients in the observation group were significantly higher than those in the control group(P<0.05).4)There was no significant difference in the levels of ALT,AST,CCr,BUN and the incidence of adverse reactions between the 2 groups(P>0.05).Conclusion:Fengke Decoction combined with acupoint Application can improve the curative effects,reduce the level of inflammation,improve the symptoms and quality of life.