血小板与类风湿关节炎中医证候相关性初探

类风湿关节炎(RA)病情复杂,病程较长,致残率高。现代医学对于本病病因及发病机制研究尚未完全明确,且常规慢作用抗风湿药、激素等不良反应明显,而中医药对本病临床疗效确凿。然而,由于类风湿关节炎中医的辨证分型尚缺乏统一客观标准,加之地域等因素,如何提高辨证的准确性成为提高RA中医药疗效的关键。为此,作者通过对文献的梳理和研究发现,血小板数量(PLT)与RA的发生和活动性等方面密切相关,并与中医热证(湿热痹阻)和瘀证(痰瘀互结等)呈正相关,从而在临床实践过程中,关注血小板等实验室指标,以期为RA中医证候诊断提高有价值的参考和借鉴。

Research on Relevance between Platelet and Traditional Chinese Medicine Syndrome of Rheumatoid Arthritis

Rheumatoid Arthritis (RA) is a complicated disease with long illness history and high disability rate. From modern medicine, the etiology and pathogenesis of the disease is not yet entirely clear. Besides, the conventional drugs such as disease-modifying anti-rheumatic drugs (DMARDs) and hormone have obvious side effects. However, traditional Chinese medicine (TCM) has definite efficacy for RA treatment. Due to lack of objective standard for TCM syndrome diagnosis, how to improve the accuracy of syndrome diagnosis becomes the key issue. By literature analysis, it is found that platelet has close relationship with RA occurrence and activity, and meanwhile, platelet has positive correlation with heat syndrome and stasis syndrome. Therefore, we primarily explored relationship between platelet sand TCM syndrome to provide objective evidence for the TCM syndrome diagnosis of RA for efficacy improvement.