龙牡壮骨颗粒对糖皮质激素所致大鼠骨质疏松症作用研究

目的:探讨龙牡壮骨颗粒对糖皮质激素所致骨质疏松症大鼠的治疗效果。方法:采用低钙饲料饲养加肌注氢化泼尼松的方法制备大鼠骨质疏松症模型。造模成功后,复方组、中药成分组、化药成分组、模型组大鼠分别灌胃龙牡壮骨颗粒复方、龙牡壮骨颗粒中药成分、龙牡壮骨颗粒化药成分及蒸馏水,正常对照组大鼠给予正常饲料饲养,不予造模。给药35 d后测定相关指标。结果:复方组大鼠体重、胸腺指数、血钙、血磷、股骨干重、骨钙、干骺端皮质外径、骨密度、骨干髓质密度、皮质密度、骨密度等指标明显优于模型组,尿钙含量则显著低于模型组。结论:龙牡壮骨颗粒对糖皮质激素所致骨质疏松症大鼠有良好治疗效果。

Study on Effects of Longmu Zhuanggu Granule in Treating Glucocorticoid-resulted Rat Osteoporosis

To investigate the effects of Longmu Zhuanggu Granule on glucocorticoid-induced osteoporosis rats. Methods:Rat osteoporosis models were prepared with low calcium feed and muscle injection with hydride prednisone. Compound group, Chinese medicine group, chemical medicine group, and model group of rats were given Longmu Zhuanggu Granule, its Chinese medicine, its chemical medicine, and distilled water respectively by intragastric administration. Normal control rats were feed with normal fodder. Related indicators were detected after 35 days of administration. Results:Indicators of the compound group of rats, such as body weight, thymus index, calcium and phosphorus in blood, femoral weight, bone calcium, femoral epiphysis end diameter of the cortex, bone mineral density, the density of backbone medulla, cortical density, bone mineral density, etc, were significantly superior to the model group. Urinary calcium of the compound group of rats was significantly lower than that of the model group. Conclusion:Longmu Zhuanggu Granule possesses a well therapeutic effect on glucocorticoid-induced osteoporosis.