脑益智方联合康复训练治疗肌张力低下型脑性瘫痪临床观察

目的:观察醒脑益智方联合康复训练治疗肌张力低下型脑性瘫痪的临床疗效,并分析其机制。方法:随机选取于2014年1月至2015年12月恩施州中心医院康复门诊及住院的2~6岁肌张力低下型脑性瘫痪患儿120例,按随机数字表法随机分为观察组和康复组,每组60例,同时选取20例同期同院体检科体检的正常健康患儿作为对照组。康复组予以康复训练,观察组予以康复训练结合醒脑益智方治疗。同时对各组患者进行的GMFM量表的评估,测定其肌力的变化,并抽取血液测定转化生长因子β1和BDNF,比较各组数据的统计差异并分析其临床疗效。结果:经治疗后,观察组与康复组治疗后的GMFM、肌力与TGF-β1均较治疗前明显提高(P0.05),BDNF降低(P0.05),且观察组治疗后与对照组比较较,差异无统计学意义(P0.05)。结论:醒脑益智方联合康复训练可以有效改善治疗肌张力低下型脑性瘫痪临床症状,改善其肌力,提高患儿的生活能力水平,值得推广使用。

Effects of Xingnao Yizhi Fang Combined with Rehabilitation Training on Children with Cerebral Palsy Due to Dystonia and its Effect on Transforming Growth Factor Beta 1 and Nerve Remodeling in Children

To observe the clinical curative effect of Xingnao Yizhi Fang combined with rehabilitation training in the treatment of atonic cerebral palsy, and to analyze its mechanism. Methods:A total of 120 cases of children with cerebral palsy due to dystonia aging 2-6 years old who were treated in outpatient department and hospitalization department in our hospital from January 2014 to December 2015 were selected and divided into treatment group and rehabilitation group with 60 cases in each. And 20 cases of healthy children from physical examination department of our hospital were selected as control group. The rehabilitation group was given rehabilitation training, and the treatment group was given rehabilitation training combined with Xingnao Yizhi decoction. At the same time, the GMFM scale of each group was evaluated, and the changes of muscle strength were measured. The blood samples were taken to determine TGF-beta 1 and BDNF. The statistical difference of each group''s data was analyzed and the clinical efficacy was also analyzed. Results:After treatment, GMFM, muscle strength and TGF-beta 1 were of the treatment group and rehabilitation group after treatment were significantly increased (P<0.05), and BDNF was decreased (P<0.05). There was no statistically significant difference between treatment group and control group after treatment (P>0.05). Conclusion:Xingnao Yizhi Fang combined with rehabilitation training can effectively improve the clinical symptoms of patients with low tension cerebral palsy, improve the muscle strength and the living ability of children, so it is worth popularizing.