参芎注射液联合硫酸镁和拉贝洛尔治疗妊娠期高血压的临床疗效观察

目的:探究参芎注射液联合硫酸镁和拉贝洛尔治疗妊娠期高血压的临床疗效及其相关机制。方法:选取2017年6月至2018年6月武警北京总队医院产科收治的妊娠期高血压患者156例作为研究对象,按随机数字表法随机分为对照组和观察组,每组78例。对照组给予常规治疗+硫酸镁+拉贝洛尔,观察组在对照组治疗的基础上加用参芎注射液,连续治疗2周。观察2组患者的临床疗效及其血管内皮功能指标(PGI2、TXA2、ET-1、NO)、氧化应激指标(LPO、GSH-PX、SOD、MDA)、血清炎性反应因子(IL-6、TNF-α、CRP)、血压水平变化情况。结果:治疗后,2组患者ET-1、TXA2、LPO、MDA水平明显降低,PGI2、NO、GSH-PX、SOD水平明显升高,观察组上述指标变化更明显,差异有统计学意义(P<0.05)。治疗后,2组患者IL-6、TNF-α、CRP、收缩压、舒张压、S/D比值、阻力指数水平明显降低,观察组上述指标变化更明显,差异有统计学意义(P<0.05)。观察组治疗后的总有效率(93.59%)明显高于对照组(80.77%),差异有统计学意义(P<0.05)。结论:参芎注射液联合硫酸镁、拉贝洛尔治疗妊娠期高血压病可通过抗炎、抑制氧化应激反应、保护血管内皮功能,提高妊娠期高血压患者的临床治疗效果。

Observation of Clinical Curative Effects of Shenxiong Injection Combined with Magnesium Sulfate,Labetalol in The Treatment of Pregnancy Induced Hypertension

Objective:To explore clinical curative effects and related mechanism of Shenxiong Injection combined with magnesium sulfate,labetalol in the treatment of pregnancy induced hypertension.Methods:A total of 156 patients with pregnancy induced hypertension were divided into a control group and an observational group according to the random number table method,with 78 cases in each group.The control group was given conventional treatment+magnesium sulfate+labetalol,while the observational group was given Shenxiong Injection based on the treatment of the control group of for the consecutive 2 week treatment.The clinical efficacy,endothelial function index(PGI2,TXA2,ET-1,NO),oxidative stress index(LPO,GSH-Px,SOD,MDA),serum inflammatory cytokines(IL-6,TNF-α,CRP)and the level of blood pressure were observed of 2 groups.Results:After treatment,the levels of ET-1,TXA2,LPO and MDA of 2 groups decreased significantly,while the levels of PGI2,NO,GSH-Px and SOD increased significantly.The above indexes changed more obviously and the differences were statistically significant(P<0.05).After treatment,the level of IL-6,TNF-α,CRP,systolic pressure,diastolic pressure,S/D ratio,the resistance index levels of 2 groups decreased significantly,and the above indexes changed more obviously of the observational group.The differences were statistically significant(P<0.05).The total effective rate of the observational group after treatment(93.59%)was significantly higher than that of the control group(80.77%),and the difference was statistically significant(P<0.05).Conclusion:Shenxiong Injection combined with magnesium sulfate,labetalol in the treatment of pregnancy induced hypertension can be anti-inflammatory,inhibiting oxidative stress reaction,and protecting endothelial function,so as to improve the effects of clinical treatment.