参元益气活血胶囊对不稳定型心绞痛气虚血瘀证患者择期PCI围术期ACE2的影响

目的:观察参元益气活血胶囊对择期经皮冠状动脉介入(PCI)气虚血瘀者患者围术期ACE2的影响,探讨该药的临床新用途。方法:采用前瞻性、随机、双盲、安慰剂、对照的临床试验方案观察对照组及观察组对择期PCI的不稳定型心绞痛(UA)患者血清中ACE2、ERK、PKC水平的影响,同时观察参元益气活血胶囊对择期PCI围术期心绞痛的临床疗效。结果:2组PCI术前ACE2、ERK、PKC差异无统计学意义(P0.05);对照组术后血清中ACE2、ERK、PKC水平有所升高,提示存在一定的围术期心肌损伤;观察组术后血清中ACE2、ERK、PKC水平较术前水平升高,与对照组比较差异有统计学意义(P0.05)。2组患者PCI术后心绞痛发作均明显减少,显效率相当,总有效率观察组略高,但差异无统计学意义(P0.05)。结论:参元益气活血胶囊对择期PCI围术期心肌损伤具有一定的保护作用。

Shenyuan Yiqi Huoxue Capsule on ACE2 of Patients with Unstable Angina of Qi-deficiency and Blood-stagnation Syndrome after PCI in Preoperative Period

To observe the effect of Shenyuan Yiqi Huoxue capsule on ACE2 of patients with unstable angina(UA) of Qi-deficiency and Blood-stagnation syndrome after PCI in preoperative period,and explore its potential.Methods:Conduct RCTs in perspective with placebo to observe the ACE2,ERK,PKC level in the serum of patients with UA,thus studying the clinical effect of Shenyuan Yiqi Huoxue capsule.Results:Before the treatment,no statistical significance were found between the two groups in ACE2,ERK,PKC(P>0.05).While after the treatment there are significant difference in all those three levels in the treatment group and between the two groups(P<0.05).There being a rise of levels of all three in the control group after the surgery signifies myocardial damage.However,the occurrence of angina decreased in both groups after treatment,implying effectiveness; only without statistically higher total effective rate of the treatment group (P>0.05).Conclusion:Shenyuan Yiqi Huoxue capsule has effect on myocardial damage after PCI.