基于数据挖掘总结李顺民治疗慢性肾衰竭经验

目的:基于数据挖掘技术探讨李顺民教授治疗慢性肾衰竭的中医辨治用药规律。方法:收集2012年5月至2017年3月间李顺民教授诊治的慢性肾衰竭门诊病例资料,通过一维及二维的数据分析和Cytoscape软件分层可视化网络图,总结出用药规律及特点。在中国知网数据库上检索和下载慢性肾衰竭相关文献,通过筛选出名医经验类型文献,然后清洗、降噪处理后,进行数据分析,总结出慢性肾衰竭病因、症状、证候、治法、中药规律,并用Cytoscape软件将结果可视化,比较并分析李顺民教授用药特点。结果:李顺民教授在慢性肾衰竭的治疗上,多选用黄芪、山药、炙甘草、大黄、酒苁蓉、丹参、紫苏叶、芡实、白术、地黄等,并喜用甘、苦、辛药及温、平、寒药为主。文本挖掘的结果则提示,病因当以湿浊、瘀血、湿热、水湿、正虚、饮食因素等为主,症状则以水肿、乏力、恶心呕吐最常见,证候以脾肾两虚为主,治法以活血化瘀、补益脾肾为最常见的治法,中药常用大黄、黄芪、当归、茯苓、地黄、丹参、白术、半夏、黄连、全蝎等。结论:本研究采用数据挖掘技术,对李顺民教授辨治慢性肾衰竭进行用药规律分析,并以文献收集慢性肾衰竭名医经验相关文献,进行分析比较,从而客观的反映出李顺民教授治疗慢性肾衰竭注重补脾、健脾、益气、补肾助阳,兼攻下、活血化瘀、解表、固精的特点。

Analysis of Professor Li Shunmin's Experience in Treating Chronic Renal Failure Based on Data Mining

To explore Professor Li Shunmin''s Traditional Chinese medicine (TCM) diagnostic and treatment patterns in chronic renal failure. Methods:Clinical records between May 2012 and March 2017 of patients diagnosed with chronic renal failure were collected. A thorough search on chronic renal failure papers was performed through China Network Knowledge Infrastructure (CNKI) database, and famous physician experience papers were selected for analysis. TCM pathologic factors, symptoms, syndrome pattern, treatment principles, and herb usage results were mined from the selected papers before being processed and subjected to one-dimensional and two-dimensional analysis, Network diagrams were visualized using Cytoscape. Results:Professor Li Shunmin regularly used Radix Astragali, Rhizoma Dioscoreae, Radix et Rhizoma Glycyrrhizae Praeparata cum Melle, Radix et Rhizoma Rhei, Herba Cistanches, Radix et Rhizoma Salviae Miltiorrhizae, Folium Perillae, Semen Euryales, Rhizoma Atractylodis Macrocephalae and Radix Rehmanniae in the treatment of chronic renal failure. Warm, neutral, cold, sweet, bitter and acrid were the most frequently used herb properties. The main pathologic factors were turbid dampness, blood stasis, dampness heat, dampness water, weakened body resistance and dietary factors. Main symptoms were edema, weakness, nausea and vomiting. Main syndrome pattern was spleen and kidney deficiency. Main treatment principles obtained were blood invigorating stasis dissipating and tonifying the spleen and kidney. Most commonly used herbs were Radix et Rhizoma Rhei, Radix Astragali, Radix Angelicae Sinensis, Poria, Radix Rehmanniae, Radix et Rhizoma Salviae Miltiorrhizae, Rhizoma Atractylodis Macrocephalae, Rhizoma Pinelliae, Rhizoma Coptidis, Scorpio. Conclusion:Through data mining, both Professor Li Shunmin''s diagnostic and herbal prescribing patterns were analyzed. Famous physician papers were collected and analyzed, followed by result comparison with that of Professor Li Shunmin''s. Through these comparisons, the unique characteristics were derived, such as tonfying the spleen, strengthening the spleen, tonifying qi, tonifying kidney yang, purgating, blood invigorating stasis dissipating, relieving external syndrome and essence controlling in Professor Li Shunmin''s chronic renal failure treatment.