| 龙葵碱抗肿瘤作用及机制 |
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| 引用本文： | 闫霞,郑佳露,胡兵.龙葵碱抗肿瘤作用及机制[J].世界中医药,2017(9). |
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| 作者姓名： | 闫霞 郑佳露 胡兵 |
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| 作者单位： | 1 上海中医药大学附属龙华医院肿瘤科，中医肿瘤研究所，上海，200032； 2 上海中医药大学附属龙华医院肿瘤五科，上海，200032 |
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| 基金项目： | 国家自然科学基金(81273726，81473625）；上海市中医药事业发展三年行动计划(ZY3-CCCX-3-3025）；上海市科技支撑项目(16401902500） |
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| 摘 要： | 龙葵碱是龙葵的主要成分,主要包括澳洲边茄碱、澳洲茄碱及龙葵碱等;研究表明龙葵碱在肺癌、乳腺癌、肝癌、胰腺癌、大肠癌、宫颈癌、前列腺癌、黑色素瘤、脑胶质瘤、骨髓瘤、白血病等肿瘤中具有广泛的抗癌作用;可以抑制细胞增殖、诱导细胞凋亡、阻滞细胞周期、诱导细胞自噬、增强放化疗作用、抑制上皮-间质转化、抑制肿瘤转移和抑制血管生成;这些研究为龙葵碱的合理应用及开发提供了新的基础。
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| 关 键 词： | 龙葵碱 中药药理学 抗肿瘤作用 机制 |
| 收稿时间： | 2016/8/9 0:00:00 |
Anti-cancer Effects and Mechanism of Glycoalkaloids from Solanum nigrum L |
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| Yan Xi,Zheng Jialu,Hu Bing.Anti-cancer Effects and Mechanism of Glycoalkaloids from Solanum nigrum L[J].World Chinese Medicine,2017(9). |
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| Authors: | Yan Xi Zheng Jialu Hu Bing |
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| Institution: | 1 Institute of Traditional Chinese Medicine in Oncology, Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China; 2 The 5th Department of Oncology, Longhua hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China |
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| Abstract: | Glycoalkaloids is one of the main constituents of Solanum nigrum L., including solamargine, solasonine, and solanine. Glycoalkaloids was proved to have anti-cancer effects against lung cancer, breast cancer, liver cancer, pancreatic cancer, colorectal cancer, cervical cancer, prostate cancer, leukemia and other malignancies. Glycoalkaloids can inhibit cell proliferation, induce apoptosis and autophagy, block cell cycle, enhance effects of chemotherapy, inhibit epithelial-mesenchymal transition, metastasis and angiogenesis. These studies provide new basis for rational application and development of Glycoalkaloids. |
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| Keywords: | Solanum Glycoalkaloids Pharmacology of Chinese materiamedica Anti-cancer effects Mechanism |
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