首荟通便胶囊预防肝胆胰恶性肿瘤化疗后便秘的疗效观察

目的:探讨首荟通便胶囊预防肝胆胰恶性肿瘤化疗后便秘的临床疗效。方法:选取2016年8月至2018年8月河北医科大学第二医院肝胆外科收治的老年肝胆胰恶性肿瘤化疗患者80例作为研究对象,按照随机数字表法随机分为对照组和观察组,每组40例。对照组口服乳果糖口服液,观察组在对照组基础上加服首荟通便胶囊。治疗14 d后,比较2组的临床疗效。结果:中医病症临床疗效观察,对照组总有效率达到75%;观察组,总有效率达到90%,2组比较差异有统计学意义(P<0.05)。临床症状评分观察,对照组总有效率达到77.5%;观察组总有效率达到92.5%,2组比较差异有统计学意义(P<0.05)。排便评分(VAS评分)观察,治疗后对照组排便间隔时间和每次排便时间均长于观察组,2组VAS评分比较,差异均有统计学意义(P<0.05)。结论:首荟通便胶囊可以有效预防肝胆胰恶性肿瘤化疗后的便秘,有效缓解患者排便疼痛程度,减少排便时间,效果显著,值得临床推广。

Observation on the Efficacy of Shouhui Tongbian Capsule in Preventing Constipation after Chemotherapy for Hepatobiliary and Pancreatic Malignant Tumors

To investigate the clinical effects of Shouhui Tongbian Capsule in treating constipation after chemotherapy for hepatobiliary pancreatic malignancy tumors.Methods:A total of 80 cases of elderly hepatobiliary and pancreatic malignant tumor chemotherapy patients admitted to the oncology department of the Second Hospital of Hebei Medical University from August 2016 to August 2018 were selected and randomly divided into an observation group and a control group, with 40 cases in each group according to random number table method.The control group took lactulose oral liquid orally, and the observation group was added to the control group with Shouhui Tongbian Capsule.After continuous treatment for 14 days, the clinical effects of the 2 groups were compared.Results:The clinical efficacy of TCM diseases and syndromes were observed.The total effective rate in the control group reached 75% and the total effective rate in the observation group reached 90%.There was a statistically significant difference between the 2 groups (P<0.05).The clinical symptom score observation showed that the total effective rate of the control group reached 77.5% and the total effective rate of the observation group reached 92.5%.There was a statistically significant difference between the 2 groups (P<0.05).The defecation score (VAS score) was observed.After treatment, the defecation interval of the control group was reduced to (2.87±0.77) d, which was higher than that of the observation group(2.02±0.54) d.The defecation time of the control group was (11.37±2.83) min, which was longer than the observation group (7.25±2.25) min.The VAS score showed that the differences between the 2 groups were statistically significant (P<0.05).Conclusion:Shouhui Tongbian Capsule can effectively prevent constipation after chemotherapy of hepatobiliary and pancreatic malignant tumors, effectively alleviate the degree of defecation pain and reduce the time of defecation.