六味地黄丸对更年期综合征患者神经内分泌免疫网络的影响

目的:观察六味地黄丸对更年期综合征患者生命质量的影响,并探讨其对机体神经内分泌免疫网络的干预效应。方法:选取2011年1月至2016年1月南京医科大学附属明基医院国际医疗部收治的更年期综合征患者80例,随机分为对照组和观察组,每组40例。2组患者均予雌二醇/醋酸炔诺酮片口服,观察组在上述药物治疗基础上加用六味地黄丸,2组均以3个月为1个疗程,疗程结束后比较2组临床疗效、生命质量评分、NE(去甲肾上腺素)、DA(多巴胺)、5-HT(五羟色胺),5-HIAA(5-羟吲哚乙酸)浓度的变化。结果:1)2组患者的中医证候积分均较治疗前有所下降(P0.05),其中观察组下降的趋势更明显,与对照组比较(P0.05)。2)2组治疗后SF-36维度均较治疗前上升(P0.05),其中观察组增加的评分较对照组明显增多(P0.05);3)2组治疗后DA、5-HT、5-HIAA浓度较治疗前明显下降(P0.05),NE含量明显回升(P0.05),观察组在上述各指标的改善程度较对照组明显(P0.05)。结论:六味地黄丸可明显改善更年期综合征患者的生命质量,其作用机制可能通过调节患者神经内分泌免疫实现。

Effects of Liuwei Dihuang Pills on Neuroendocrine Immune Network in Patients with Menopausal Syndrome

To observe the impact of Liuwei Dihuang Pills on the quality of life of the patients with menopausal syndrome, and to explore the intervention effect on neuroendocrine immune network of the body. Methods:A total of 80 patients with climacteric syndrome in our hospital during January 2011 to January 2016 were included and randomly divided into the control group and the observation group, with 40 cases in each group. The two groups of patients all had oral administration of estradiol/norethindrone acetate tablets, and the observation group took Liuwei Dihuang Pills on the basis of the above drug therapy. Both groups were treated for three months as a course of treatment. After treatment, the clinical curative effect, life quality scores, the concentration of NE (norepinephrine), DA (dopamine), 5-HT (serotonin), 5-HIAA (5-hydroxy indole acetic acid), and the percentage changes of Th17 cell of two groups were compared. Results:1) The TCM syndrome scores of two groups were decreased after treatment (P<0.05). The decrease trend of observation group was significantly significant than that of the control group (P<0.05).2) After treatment, SF-36 dimensions were increased in the two groups than before treatment (P<0.05), and the increase scores of the observation group was significantly larger than the control group (P<0.05); 3) The concentration of DA, 5-HT, 5-HIAA of the two groups after treatment significantly decreased than before treatment (P<0.05), and the NE content rebounded significantly (P<0.05). The improvement of the above-mentioned indexes in the observation group was more significant than the control group (P<0.05). Conclusion:Liuwei Dihuang Pills can significantly improve the quality of life of patients with menopausal syndrome, and the mechanism of action may realized by adjusting the neuroendocrine immune of the patients.