菖蒲汤加减辨治血管性认知功能障碍的疗效及部分机制探讨

目的：观察菖蒲汤加减辨治血管性认知障碍（Vascular Cognitive Impairment，VCI）的临床疗效，并对其部分作用机制进行探究。方法：选取2017年3月至2018年3月北京市大兴区中西医结合医院血管性认知障碍患者96例作为研究对象，按照就诊顺序编号，随机分为对照组和观察组，每组48例。对照组西医治疗，观察组加用菖蒲汤加减治疗，均同时治疗8周。观察2组MoCA评分、脑血流变化、氧化应激指标变化以及临床疗效比较。结果：1)完成治疗后2组MOCA、MCA、ACA、PCA、BA、VA、SOD、GSH-Px、CAT、组BVL、BVM、BVH、FIB较治疗前均显著升高（P<0.05），观察组优于于对照组，差异有统计学意义（P<0.05）。2)完成治疗后观察组临床痊愈率、总有效率均显著高于对照组，差异有统计学意义（P<0.05）。结论：菖蒲汤加减能促进血管性认知障碍血液循环，提高氧化应激水平，从而改善症状，提高疗效。

Discussion on the Therapeutic Effects and SomeMechanism of Modified Changpu Decoction on Vascular Cognitive Impairment

To explore the therapeutic effects of modified Changpu Decoction on vascular cognitive dysfunction (VCI),and to explore its some mechanism.Methods:A total of 96 patients with vascular cognitive impairment were randomly divided into a control group ( n=48 ) and a study group ( n=48 ).The control group was treated with Western medicine,and the study group was treated with modifed Changpu Decoction for 8 weeks.The changes of MoCA score,cerebral blood flow,oxidative stress index and clinical curative effects were observed and compared between the 2 groups.Results:1) After treatment,MOCA,MCA,ACA,PCA,BA,VA,SOD,GSH-Px,CAT,group BVL,BVM,BVH and FIB in the 2 groups were significantly higher than those before treatment,and the study group was superior to the control group (P<0.05).2) After the completion of treatment,the clinical cure rate and total effective rate in the study group were significantly higher than those in the control group,and the difference was statistically significant (P<0.05).Conclusion:Changpu Decoction could promote the blood circulation of vascular cognitive dysfunction and increase the level of oxidative stress,so as to improve the symptoms and improve the curative effect.