益母草注射液联合缩宫素对子宫收缩能力及产后出血的影响

目的:探究益母草注射液联合缩宫素对剖宫产产妇子宫收缩能力及产后出血的影响。方法:选取2016年1月至2016年12月南京市中医院行剖宫产的产妇100例,按照随机数字表法随机分为观察组和对照组,每组50例。对照组在剖宫产胎儿娩出后向子宫壁注射缩宫素20 U,观察组在对照组的基础上给予益母草注射液,2组均治疗3 d。统计2组治疗后产妇出血量,检测2组治疗前后血常规及凝血功能,比较2组产后72 h子宫收缩能力及复旧情况,统计2组临床疗效。结果:2组产妇产后1～72 h出血量均逐渐降低(均P 0. 01),且观察组显著低于对照组(P 0. 01);观察组产后出血率为2. 00%,对照组为10. 00%,2组比较差异无统计学意义(P 0. 05);与治疗前比较,对照组Hb、RBC水平显著降低(P0. 05或P 0. 01),观察组治疗前后无显著变化(P 0. 05),观察组Hb、RBC水平显著高于对照组(P 0. 05或P 0. 01); 2组APTT、PT时间治疗前后及组间比较,差异均无统计学意义(P 0. 05)。产后72 h,观察组产妇宫缩幅度、强度及张力显著高于对照组(P 0. 01),宫缩频率显著低于对照组(P 0. 05);观察组产妇宫底下降程度、子宫三径之和、恶露持续时间显著低于对照组(P 0. 01);观察组宫腔总积血率为8. 00%,显著低于对照组的28. 00%(P 0. 05)。治疗后观察组临床总有效率96. 00%,显著高于对照组的78. 00%(P 0. 01)。结论:益母草注射液联合宫缩素可有效降低剖宫产产妇出血量,提高止血效果,且对患者凝血功能影响较小,可增强子宫收缩能力,促进子宫复旧,效果优于单独缩宫素治疗。

Effects of Leonurus Injection Combined with Oxytocin on Uterine Contractile Ability and Postpartum Bleeding

To explore the effects of leonurus injection combined with oxytocin on the uterine contractile ability and postpartum hemorrhage of cesarean section parturient.Methods:A total of 100 parturients underwent cesarean section in Nanjing Hospital of Chinese Medicine from January 2016 to December 2016 were selected and divided into control group (n=50) and treatment group (n=50) according to random number table method.Control group was given oxytocin 20 U into the uterine wall after cesarean section delivery,treatment group was given leonurus injection on the basis of control group,and 2 groups were treated for 3 days.The amount of postpartum hemorrhage in 2 groups was statistically analyzed after treatment,the blood routine and coagulation function in 2 groups were measured before and after treatment,the uterine contractile ability 72 hours after postpartum and rehabilitation status in 2 groups were compared,and the clinical efficacy in 2 groups was statistically analyzed.Results:The amount of postpartum hemorrhage in 2 groups decreased gradually from 1 to 72 hours after postpartum (P<0.01),of which the treatment group was significantly lower than the control group (P<0.01).The postpartum hemorrhage rate in treatment group was 2.00%,which was lower than 10.00% in control group,but there was no significant difference (P>0.05).Compared with before treatment data,the Hb and RBC levels in control group significantly decreased (P<0.05 or P<0.01),there was no significant change in treatment group before and after treatment (P>0.05).The Hb and RBC levels in treatment group were significantly higher than those in control group (P<0.05 or P<0.01),and there was no significant difference between the APTT and PT times of 2 groups before and after treatment (P>0.05).The amplitude,intensity and tension of parturient uterine contractions in treatment group were significantly higher than those in control group 72 hours after postpartum (P<0.01),and the frequency of uterine contractions in treatment group was significantly lower than in control group (P<0.01),which was significantly lower than control group (P<0.05 or P<0.01).The descent degree of uterine fundus,the sum of uterus three meridians and the duration of lochia in treatment group were significantly lower than that of control group (P<0.01),and the total uterine cavity hematocele rate in treatment group was 8.00%,which was significantly lower than 28.00% in control group (P<0.05); the total clinical efficiency in treatment group after treatment was up to 96.00%,which was significantly higher than 78.00% in control group (P<0.01).Conclusion:Leonurus injection combined with oxytocin can effectively reduce the amount of cesarean section postpartum hemorrhage,improve the hemostasis effect,and have less effects on its coagulation function,enhance uterine contractile ability,promote the uterine rehabilitation,and the effect is better than oxytocin treatment alone.