不同产地生附子同剂量的破格救心汤结合西医常规治疗对难治性心衰的心功能影响

目的:分析探讨不同产地生附子同剂量的破格救心汤结合西医常规治疗对难治性心衰心功能的影响。方法:选择我院2015年3月至2015年10月期间收治的难治性心衰患者80例作为本次研究的对象,使用信封抽取法将这80例患者分成治疗组和对照组,每组各40例,对照组给予西医常规治疗,治疗组采取不同产地生附子(云南和河南)同剂量的破格救心汤结合西医常规治疗,并在治疗结束后,对比分析2组患者的治疗效果。结果:治疗组治疗后的心功能分级优于对照组(P0.05);治疗组治疗后的中医证候积分为(17.04±5.23)分,对照组治疗后的中医证候积分为(35.67±5.98)分;治疗组治疗后的左室射血分数和心输出量均高于对照组(P0.05);云南和河南生附子的破格救心汤均具有较好的治疗效果,治疗总有效率差异无统计学意义(P0.05),但云南生附子组的不良反应率多于河南生附子组(P0.05)。结论:不同产地生附子同剂量的破格救心汤结合西医常规治疗对难治性心衰具有较好的疗效。

Treatment of Refractory Heart Failure by Different Producing Area and Same Dose of Aconite Root Contained Poge Heart-saving Decoction Combined with Conventional Western Medicine

To explore the effect of different producing area and same dose of Aconite Root contained Poge Heart-saving Decoction combined with conventional western medicine in the treatment of heart failure and its effect on heart function.Methods:A total of 80 cases of refractory heart failure patients in our hospital during March 2015 to October 2015 were divided into experimental group and control group by envelope extraction method,40 cases in each group.The control group was treated with routine western medicine while the experimental group took different producing areas (Yunnan and Henan) but same dose of Aconite Root contained Poge Heart-saving Decoction combined with routine western medicine treatment.The therapeutic effect of two groups was compared at the end of the treatment.Results:Heart function classification of the experimental group was better than that of the control group (P<0.05); Chinese medicine syndrome score of the experimental group was (17.04 ±5.23),the control treatment group was (35.67±5.98); left ventricular shoot ejection fraction and cardiac output of the experimental group were higher than those of the control group (P<0.05); Aconite Root produced in Yunnan and Henan both had good effect and their clinical efficacy had no significant difference (P>0.05),but Yunnan Aconite Root showed more adverse reaction than Henan Aconite Root (P<0.05).Conclusion:Different areas of the same dose of Aconite Roots contained Poge Heart-saving Decoction combined with routine western medicine has good clinical effect on refractory heart failure.