寿胎II号协定方联合黄体酮辨治肾虚型胎动不安的临床研究

目的:探讨寿胎II号协定方联合黄体酮辨治肾虚型胎动不安的临床效果。方法:选择2014年6月至2015年9月我院收治的肾虚型胎动不安患者110例,随机分为对照组和观察组患者各55例。对照组患者给予黄体酮肌肉注射,观察组则联合给予寿胎II号协定方内服治疗。对比2组的临床疗效,评价主要中医证候积分,监测治疗前后血清激素水平变化,随访统计患者的分娩情况。结果:观察组的有效率90.9%高于对照组患者74.5%(P0.05);观察组患者的腰酸、腹痛、小腹下坠、阴道少量下血等症状改善优于对照组患者,证候积分显著低于对照组患者(P0.05);观察组患者血清β-HCG、P水平显著高于对照组患者(P0.05);观察组的分娩结局明显优于对照组患者(P0.05)。结论:寿胎II号协定方联合黄体酮辨治肾虚型胎动不安患者疗效肯定,能显著改善临床症状,提高保胎成功率,其机制与提高血清激素水平密切相关,是中西医结合保胎效果的突出体现,值得临床推广运用。

Clinical Study of Shoutai II Decoction combined with Progesterone on Fetal Irritability of Kidney Deficiency Pattern

To investigate the clinical effect of Shoutai II Decoction combined with progesterone on fetal irritability of kidney deficiency pattern. Methods: A hundred and ten patients with fetal irritability due to deficiency of the kidney admitted in the hospital from June 2014 to 2015 September randomly assigned for the control group and the observation group with 55 cases in each. Patients in the control group were treated with progesterone intramuscular injection and the observation group was additionally treated with Shoutai II Decoction. The clinical efficacy of the two groups was compared and the main TCM syndrome score was evaluated. The changes of serum hormone level before and after treatment were monitored. Results: The effective rate of the observation group was 90.9% higher than that of the control group (74.5%) (P<0.05); symptoms like backache, abdominal pain, abdominal straining, vaginal a small amount of blood and other of the observation group relieved better than those of the control group patients. Syndrome score was significantly lower than that of the patients in the control group (P<0.05). Serum beta hCG and P levels of patients in the observation group were was significantly higher than that of the control group (P<0.05); delivery outcome in the observation group was significantly better than that of the control group (P<0.05). Conclusion: Shoutai II Decoction combined with progesterone in treating patients with irritability of kidney deficiency pattern received good therapeutic effect and may significantly improve the clinical symptoms and improve the success rate of miscarriage. The mechanism may be associated with increased serum hormone levels and closely related to the Integration of Chinese traditional and Western medicine, which is worthy of clinical popularization and application.