嘌呤配体P2X门控离子通道型受体7及其下游分子在痛风性关节炎中作用机制的研究进展

目前随着痛风性关节炎的发病率逐年上升,对该病炎性反应及疼痛机制的研究越来越多,该病主要由尿酸盐沉积及ATP刺激P2X7R、Nod样受体蛋白3、NEK7表达诱导炎性反应递质成熟与分泌所致,但具体机制尚不明确。现对P2X7R、NLRP3、NEK7的国内外研究进展进行综述,以探讨GA炎性反应及疼痛的发病机制,为防治GA提供新思路与治疗靶点。

Progress in the Mechanism of Purinergic Receptor P2X, Ligand-gated Ion Channel 7 and its Downstream Molecules in Gouty Arthritis

At present,with the increasing incidence of gouty arthritis year by year,more and more studies have been done on the inflammatory reaction and pain mechanism of gouty arthritis.Scholars believe that the disease is mainly caused by the deposition of uric acid and ATP stimulating the expression of P2X7R,NLRP3 and NEK7 to induce the maturation and secretion of inflammatory factors,but the specific mechanism is still unclear.Therefore,this paper reviewed the research progress of P2X7R,NLRP3 and NEK7 at home and abroad,in order to explore the pathogenesis of inflammation and pain in GA,and to provide new ideas and therapeutic targets for the prevention and treatment of GA.