活血化瘀汤治疗急性脑梗死患者NT-proBNT、血清炎性因子、神经功能及Copeptin水平的影响

目的:探讨活血化瘀汤治疗急性脑梗死患者N-末端脑钠素原(NT-pro BNT)、血清炎性因子、神经功能及和肽素(Copeptin)水平的影响。方法:114例急性脑梗死患者根据随机数字表法随机分为观察组(n=57)与对照组(n=57)。对照组采用常规治疗,观察组在对照组基础上结合活血化瘀汤治疗。2组总疗程为14 d。对比分析2组NT-pro BNT、Copeptin、白介素-6(IL-6)、超敏-C反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α)、神经功能缺损程度(NIHSS)评分、日常生活能力(ADL)评分、疗效及药物不良反应。结果:2组血清NT-pro BNT、copeptin水平治疗后低于治疗前(P0.05);观察组血清NT-pro BNT、copeptin水平治疗后低于对照组(P0.05);2组血清IL-6、hs-CRP、TNF-α治疗后低于治疗前(P0.05);观察组血清IL-6、hs-CRP、TNF-α治疗后低于对照组(P0.05);2组NIHSS评分治疗后低于治疗前(P0.05),而ADL评分高于治疗前(P0.05);观察组NIHSS评分治疗后低于对照组(P0.05),而ADL评分高于对照组(P0.05);观察组总有效率(89.47%)高于对照组(68.42%)(P0.05);治疗期间2组均未见严重药物不良反应。结论:活血化瘀汤可降低急性脑梗死患者NT-pro BNT、Copeptin、血清炎性因子水平,改善患者神经功能,提高患者日常生活能力。

Effect of Huoxue Huayu Decoction on NT-proBNT, Serum inflammatory factors, Neurological function and Copeptin level of Patients with Acute Cerebral Infarction

To observe the effect of Huoxue Huayu decoction on N-terminal brain natriuretic peptide (NT-proBNT), serum inflammatory factor, nerve function and peptide(copeptin) level in patients with acute cerebral infarction. Methods: A total of 114 patients with acute cerebral infarction were randomly divided into observation group(n=57) and control group(n=57) according to the random number table. The control group was treated with routine treatment, while the observation group was treated with Huoxue Huayu decoction except for the medication of the control group. The total duration of the two groups was 14d. Compare and analyze the NT-proBNT, copeptin, interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hs CRP) and tumor necrosis factor alpha (TNF alpha), neural function defect degree (NIHSS), ability of daily life (ADL) score, therapeutic efficacy and side effects of the two groups. Results: The levels of serum NT-proBNT and copeptin in the two groups were lower than before(P<0.05). The serum level of NT-proBNT and copeptin in the observation group was lower than that of the control group (P<0.05). Serum hs-CRP, TNF-, IL-6 of the two groups has lowered(P<0.05). After treatment, IL-6, TNF-, hs-CRP in the observation group was lower than that of control group (P<0.05). NIHSS score has decreased(P<0.05) in both groups, and ADL score has increased(P<0.05). The NIHSS score in the observation group was lower than that of the control group (P<0.05), while the ADL score was higher than that of the control group (P<0.05).The total effective rate in the observation group(68.42%) was higher than that of the control group(89.47%)(P<0.05). No side effect was observed in the two groups during the treatment. Conclusion: Huoxue Huayu decoction can reduce the level of NT-proBNT, copeptin and serum inflammatory factors in patients with acute cerebral infarction, and thus improving neurological function and the daily life ability of patients.