高血压病不同中医肝证患者氧化应激功能变化情况的临床观察

目的:研究不同的中医肝证者机体氧化应激情况的变化。方法:选取2013年4月至2015年4月,随机选取纳入商洛市公共卫生服务高血压管理项目的高血压患者100例,对所有患者实施检测,其中肝气郁结组52例,肝气上亢组48例。再选择50例正常体检者作为对照组。对各组SOD、CAT、GSH-PX以及MDA水平和各组ET、NO以及ET/NO水平实施检测。结果:高血压患者的收缩压和舒张压均显著大于对照组,差异均有统计学意义(P0.05)。高血压患者中肝气郁结以及肝气上亢患者的SOD、CAT和GSH-PX水平均显著低于对照组;MDA水平均显著大于对照组。高血压患者中肝气郁结和肝气上亢患者的NO以及ET/NO水平均显著低于对照组;ET水平均显著大于对照组,差异均有统计学意义(均P0.05)。结论:高血压肝证者机体氧化应激作用下降,且不同肝证者具有的炎性反应情况不同。

Clinical Observation on Changes of Oxidative Stress Reaction in Patients with Hypertension of Different TCM Syndrome Types

To study changes of oxidative stress reaction in patients with hypertension of different TCM syndrome types. Methods: A total of 100 patients with hypertension randomly included in the high blood pressure management project from April, 2013 to April, 2015 under the guidance of Shangluo city public health service center were selected and divided into two groups after examination, with 52 cases belonging to liver-qi stagnation group, and 48 cases belonging to hyperactivity of liver-yang group. 50 more healthy cases were selected as control group. Then levels of SOD, CAT, gsh-px, MDA, ET, NO and ET/NO among the three groups were tested. Results: Both systolic and diastolic blood pressure of hypertensive patients was significantly higher than that in the control group, and the difference was statistically significant(P<0.05). SOD, CAT, gsh-px, NO, and ET/NO levels of patients with hypertension either due to liver-qi stagnation or hyperactivity of liver-yang were significantly lower than those in the control group, while MDA and ET levels were notably higher than those of control group, which showed a statistically significant difference(P<0.05). Conclusion: The oxidative stress reaction of hypertensive patients tends to decrease, and inflammatory reaction is different among patients with hypertension belonging to different types of liver syndrome.