丹红注射液联合单唾液酸四己糖神经节苷脂治疗糖尿病周围神经病变的疗效及对神经传导速度的影响

目的:探讨丹红注射液联合单唾液酸四己糖神经节苷脂治疗糖尿病周围神经病变(DPN)的疗效及对神经传导速度的影响。方法:选取2016年1月至2018年5月南通大学附属海安医院神经内科收治的DPN患者120例,按照入院序号奇偶分为对照组和观察组,每组60例。2组均给予常规对症治疗,对照组在常规对症治疗的基础上加用单唾液酸四己糖神经节苷脂,观察组在对照组的基础上联合丹红注射液治疗,4周为1个疗程,2组均连续治疗2个疗程。比较2组治疗后临床疗效,治疗前后血糖水平、周围神经病变的症状评分(TSS)、肢体神经传导速度变化情况。结果:观察组总有效率为90. 00%,明显高于对照组的75. 00%(P 0. 05)。治疗后2组FBG、2 h BG水平及患肢麻木、刺痛、抽筋、乏力等TSS评分均降低,且观察组更低(P 0. 05或P 0. 01)。2组在治疗后患肢正中神经、尺神经、腓总神经SNCV、MNCV均明显增加,且观察组明显大于对照组(P 0. 05或P 0. 01)。结论:丹红注射液联合单唾液酸四己糖神经节苷脂治疗DPN有效缓解患者临床症状的同时可调控其血糖水平,改善患肢神经传导速度,整体临床疗效优于单唾液酸四己糖神经节苷脂单用。

Effects of Danhong Injection Combined with Monosialic Acid Tetrahexose Ganglioside on Diabetic Peripheral Neuropathy and Its Influence on Nerve Conduction Velocity

To study the effects of Danhong injection combined with monosialic tetrahexose acid ganglioside on diabetic peripheral neuropathy (DPN) and its influence on nerve conduction velocity.Methods:A total of 120 DPN patients in the Department of Neurology of Haian Hospital affiliated to Nantong University from January 2016 to May 2018 were selected as the study subjects,and divided into the control group and the experiment group according to the hospital serial number parity,60 cases in each group.The 2 groups were treated with routine symptomatic treatment,the control group added the monosialic acid tetrahexose ganglioside on the basis of routine symptomatic treatment,the experimental group was treated with Danhong injection on the basis of the control group.The 4-week was 1 course,and the 2 groups were treated continuously for 2 courses.The clinical efficacy after treatment,blood glucose level and symptom score of peripheral neuropathy before and after treatment of TSS (Time-Sharing System) scores.Limb nerve conduction velocity changes of the 2 groups before and after treatment were compared.Results:The total effective rate of the experiment group was 90.00%,which was significantly higher than 75.00% of the control group (P<0.05).The FBG (Fasting Blood Glucose),2 hBG (2 Hours Postprandial Blood Glucose) levels and the TSS scores such as numbness,tingling,cramping and fatigue in the affected limbs significantly decreased in the 2 groups after treatment.The experimental group were significantly lower than those in the control group (P<0.05 or P<0.01).The SNCV (Sensory Nerve Conduction Velocity),MNCV (Motor Nerve Conduction Velocity) of median nerve,ulnar nerve and common peroneal nerve significantly increased in the 2 groups,and the experimental group was obviously higher than that of the control group (P<0.05 or P<0.01).Conclusion:Danhong injection combined with monosialic tetrahexose ganglioside can effectively relieve the clinical symptoms of patients with DPN and control their blood glucose level and improve nerve conduction velocity of affected limbs.The overall clinical efficacy is better than that of mouse nerve growth factor alone.