参虎半夏汤提高IIIB-IV期胃癌化疗疗效及部分机制研究

目的：评价参虎半夏汤联合CF/DCF方案治疗胃癌患者的临床疗效，探讨其相关作用机制。方法：选取2012年3月至2014年2月期间河南省中医院收治的气虚毒蕴型IIIB-IV期胃癌病患者66例，随机分成观察组（参虎半夏汤联合化疗）和对照组（化疗），每组33例。观察2组临床症状、E-cadherin、波形蛋白Vimentin浓度等临床检测指标的变化。结果：治疗后较治疗前比较：观察组的KPS评分、生活症状积分、生存期、肿瘤大小及E-cadherin表达均高于对照组，差异有显著统计学意义(P<0.01)；中医症状积分、波形蛋白Vimentin蛋白的表达均低于对照组，差异有显著统计学意义(P<0.01)。结论：参虎半夏汤可能通过诱导E-cadherin表达，抑制波形蛋白Vimentin表达，抑制肿瘤细胞侵袭浸润，减小瘤体，进而改善气虚毒蕴型IIIB-IV期胃癌患者的预后。

Clinical Studies on Shenhu Banxia Decoction in Improving Efficacy of IIIB-IV Gastric Cancer and Mechanism

To evaluate the effect of Shenhu Banxia decoction combined with CF/DCF in the treatment of patients with gastric cancer, and to explore the related mechanisms. Methods:Patients belong to the type of qi deficiency and toxin accumulation Yun IIIB-IV gastric cancer were selected according to the inclusion criteria. A total of 66 cases were randomly divided into two groups of 33 patients, observation group (Shenhu Banxia decoction combined with chemotherapy) and control group (chemotherapy). Changes were observed in clinical symptoms, E-cadherin, Vimentin concentration clinical detection indicators. Results:Compared with the condition before the treatment:The KPS score, the score of life symptom score,survival period,tumor size and E-cad expression in the observation group were higher than those in the control group, the difference was of high statistical significance(P<0.01); TCM symptom integral and Vimentin protein expression were lower than that of the control group, the difference was highly statistically significant(P<0.01). Conclusion:Shenhu Banxia decoction may inhibit the tumor cell invasion, decrease the size of tumor, then improve prognosis of the type of qi deficiency and toxin accumulation stage IIIB-IV gastric cancer patients. by inducing the expression of E-cad and inhibiting the expression of vimentin