铜绿假单胞菌耐药机制及中医药治疗研究进展

随着抗生素的不规范使用,近年细菌耐药率越来越高。临床尤以感染性疾病的多见病原菌——铜绿假单胞菌最为突出,不仅是临床急危重症的棘手问题,也是国际医学界的难题和焦点。为此,作者综述了近5年来铜绿假单胞菌耐药机制研究进展,并对β-内酰胺酶、主动外排系统、密度感应系统等主要耐药机制着力阐述,进而阐释相关的中医药治疗措施,以期为抗生素治疗无果时探索中医药治疗思路提供依据。

Research Progress on Resistance Mechanisms of Pseudomonas Aeruginosa and Treatment from Traditional Chinese Medicine

As the unreasonable application of antibiotics, the bacterial resistance rate is getting higher and higher, especially the pseudomonas aeruginosa, which was the main pathogenic bacteria in infectious diseases, and this was not only the difficult problem of clinical acute and severe diseases but also the trouble and focus internationally. Therefore, the resistant mechanism research progress of pseudomonas aeruginosa in the recent five years were reviewed. The main resistant mechanism of beta lactamase, active efflux system and quorum sensing system were focused on, and the relevant Traditional Chinese Medicine treatment were detailed, in order to provide a basis for exploring the Traditional Chinese Medicine treatment when antibiotic treatment has no efficacy.