桂枝汤加减对慢性特发性荨麻疹的疗效及血清MMP-9和25羟维生素D的检测

目的:探讨桂枝汤加减对慢性特发性荨麻疹的临床疗效,同时观察期对患者外周血清基质金属蛋白酶9(MMP-9)和25羟维生素D浓度的影响。方法:选取2015年1月至2016年12月陕西省杨凌示范区医院皮肤科门诊就诊的慢性特发性荨麻疹患者60例,随机分为对照组和观察组,每组30例。对照组患者服用氯雷他定10 mg/次,1次/d,联合西替利嗪10 mg/次,1次/d,观察组在对照组治疗基础上加用桂枝汤,2组均连续治疗28 d,治疗结束后观察2组的临床疗效,同时采用酶联免疫吸附测定(ELISA)及蛋白质免疫印迹(Western Blotting)观察2组患者治疗前后MMP-9及25羟维生素D浓度的变化。结果:1)观察组总有效率86.67%,高于对照组的66.67%,差异有统计学意义(P0.05)。2)经过治疗后,2组患者外周血25羟维生素D浓度均较治疗前升高,其中观察组升高的趋势更为明显,与对照组比较,差异有统计学意义(P0.05);3)经过治疗后2组患者外周血MMP-9浓度均较治疗前下降,其中观察组下降的幅度高于对照组,差异有统计学意义(P0.05)。

Curative Effects of Guizhi Decoction on Chronic Idiopathic Urticaria and the Detection of Serum Levels of MMP-9 and 25-hydroxyvitamin D

To investigate the clinical curative effect of Guizhi decoction on chronic idiopathic urticaria, at the same time to observe the impact on matrix metalloproteinase 9 (MMP-9) and 25-hydroxyvitamin D concentrations in the peripheral blood of the patients. Methods:A total of 60 cases of patients with chronic idiopathic urticaria who visited the dermatology clinic in our hospital included in the research were randomly divided into the control group and the observation group. The control group took loratadine 10 mg/times, 1 time/day, combined with cetirizine 10 mg/times, 1 time a day. The observation group had Guizhi decoction on the basis treatment of the control group. Both of the 2 groups had treatment for 28 days. The clinical curative effects of 2 groups after treatment was observed, and enzyme-linked immunosorbent assay (ELISA) and protein immunoblot (Western Blotting) was used to observe the concentration changes of MMP-9 and 25-hydroxyvitamin D in the 2 groups before and after treatment. Results:1) The total effective rate of the observation group was 86.67%, higher than that the total effective rate 66.67% of control group. The differences were statistically significant (P<0.05). 2) 25-hydroxyvitamin D concentration in the peripheral blood of the 2 groups increased after treatment, and the increasing trend of observation group was more significant. Compared with the control group, the difference was statistically significance (P<0.05); 3) The MMP-9 concentrations of peripheral blood of the 2 groups declined after treatment compared with before the treatment, and the falling range of the observation group was higher than control group. The differences were statistically significant (P<0.05).