急性胰腺炎患者血清白介素-8和C-反应蛋白含量变化及其临床意义

目的 :检测急性胰腺炎 (AP)患者血清白细胞介素 8(IL 8)和C 反应蛋白 (CRP)含量变化 ,探讨其临床意义。方法 :检测 30例AP患者入院时和入院后第 3、5、7天时血清IL 8和CRP含量 ,与 30例健康人作对照。结果 :入院时 ,AP患者血清IL 8和CRP含量均显著高于对照组 (P <0 .0 5 ) ,其中重症急性胰腺炎 (SAP)患者血清IL 8和CRP含量又明显高于轻症急性胰腺炎 (MAP)患者 (P <0 .0 5 )。入院后第 5、7天 ,MAP组中血清IL 8和CRP含量均显著低于入院时 (P <0 .0 5 ) ,入院后第 3天 ,SAP组中血清IL 8和CRP含量均显著性高于入院时 (P <0 .0 5 ) ,血清IL 8含量和CRP含量变化呈正相关 (r =0 .6 931,P <0 .0 5 )。结论 :血清IL 8和CRP含量变化与AP病情变化密切相关 ,联合检测有助于了解病情发展

The Changes and Significance of the Serum Interleukin-8 and C-reactive Protein in Patients with Acute Pancreatitis

Objective: To explore the serum concentration of C reactive protein (CRP) and Interleukin 8 (IL 8) and its significance in patients with acute pancreatitis (AP). Methods: The serum level of CRP and IL 8 of 30 patients were determined on admission and the 1st day, 3rd, 5th and 7th day of hospitalization and were compared with normal control group ( n =30). Results: The Serum Levels of CRP and IL 8 in patients with AP on admission were significantly higher than that of control group ( P < 0.05 ), and the levels of CRP and IL 8 in patients with severe acute pancreatitis(SAP) were significantly higher than that of moderate acute pancreatitis (MAP) ( P < 0.05 ). On the 5th and 7th day, the CRP and IL 8 levels in MAP were significantly lower than that on the first day ( P < 0.05 ), but the serum levels of CRP and IL 8 on 3rd day were significantly higher than that of the first day in SAP ( P < 0.05 ). The serum levels of CRP and IL 8 were positively correlated ( r = 0.6931 , P < 0.05 ). Conclusion: The serum levels of CRP and IL 8 were correlated to the severity of AP, detection of them are helpful in understanding of the evolvement of AP.