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Chronic alcohol consumption in alcohol-preferring P rats attenuates subsequent conditioned taste aversion produced by ethanol injections
Authors:R. B. Stewart  W. J. McBride  L. Lumeng  T. -K. Li  J. M. Murphy
Affiliation:(1) Departments of Psychiatry, Medicine and Biochemistry, Institute of Psychiatric Research and Regenstrief Institute Indiana University School of Medicine and Veterans Administration Medical Center, USA;(2) Department of Psychology, Purdue School of Science, 1125 East 38th Street, 46205-2810 Indianapolis, IN, USA
Abstract:Rats of the P line were tested for the development of tolerance to the aversive effects of ethanol during 33 days of continuous availability of food, water and a 10% (v/v) ethanol solution. Beginning on the day following the removal of ethanol, five daily conditioned taste aversion (CTA) trials were administered to the ethanol-drinking P rats and an ethanol-naive control group. The CTA trials consisted of a 20-min access to a Polycose solution, followed by IP injection of saline, 0.5, 1.0, or 1.5 g ethanol/kg. The ethanol-drinking rats developed a preference for the Polycose solution when it was paired with 0.5 g ethanol injections, but the control rats did not. Both control and ethanol groups had similar CTAs at the 1.5 g dose. However, at the 1.0 g dose, the ethanol group had an attenuated CTA compared with the water control group. The results suggest that P rats develop tolerance to aversive effects of ethanol during chronic drinking. This tolerance could contribute to the high ethanol intake in these selectively-bred rats.
Keywords:Alcohol-preferring P rats  Chronic ethanol drinking  Tolerance  Conditioned taste aversion
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