| 三七复方纳米颗粒剂抑制血栓形成作用及机制初探 |
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| 引用本文： | 张君利,贾 乘,苑 博,汪 洋,程嘉艺. 三七复方纳米颗粒剂抑制血栓形成作用及机制初探[J]. 中国实验方剂学杂志, 2010, 16(2): 81-83 |
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| 作者姓名： | 张君利 贾 乘 苑 博 汪 洋 程嘉艺 |
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| 作者单位： | 1. 辽宁中医药大学,辽宁,沈阳,110032
2. 沈阳医学院奉天医院,辽宁,沈阳,110031 |
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| 基金项目： | 辽宁省自然科学基金项目(20062055) |
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| 摘 要： | 目的:研究三七复方纳米颗粒剂抑制血栓形成作用并探讨其作用机制。方法:建立电刺激致大鼠血栓模型,观察三七复方纳米颗粒剂抗血栓作用以及对血液流变学的影响;建立肾上腺素加冰浴致大鼠血瘀模型,观察其对血栓素A2(TXA2)和前列环素I2(PG I2)的影响。结果:与对照组比较,给予三七复方纳米颗粒剂各剂量组以及阿司匹林组均能明显延长电刺激所致动脉血栓的形成时间,降低血液黏度,显著升高血瘀模型大鼠血浆中6-酮-前列环素F1α(6-Keto-PGF1α)的含量(P0.01)和6-Keto-PGF1α/TXB2值(P0.01),降低TXB2的含量(P0.05)。结论:三七复方纳米颗粒剂具有抗血栓作用,其作用机制与降低血液黏度和改变PG I2/TXA2比值有着密切的关系。
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| 关 键 词： | 三七 血栓 血液流变 血栓素A2 前列环素I2 |
| 收稿时间： | 2009-07-28 |
The Effect and Mechanism of Radix Notoginseng Compound on Inhibition of Thrombosis |
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| ZHANG Jun-li,JIA Cheng,YUAN Bo,WANG Yang and CHENG Jia-yi. The Effect and Mechanism of Radix Notoginseng Compound on Inhibition of Thrombosis[J]. China Journal of Experimental Traditional Medical Formulae, 2010, 16(2): 81-83 |
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| Authors: | ZHANG Jun-li JIA Cheng YUAN Bo WANG Yang CHENG Jia-yi |
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| Affiliation: | Liaoning University of Traditional Chinese Medicine,Shengyang 110032, China;Fengtian Hospital of Shenyang Medical Colloge,Shenyang 110031,China;Liaoning University of Traditional Chinese Medicine,Shengyang 110032, China;Liaoning University of Traditional Chinese Medicine,Shengyang 110032, China;Liaoning University of Traditional Chinese Medicine,Shengyang 110032, China |
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| Abstract: | Objective:To study the effect and mechanism of Radix Notoginseng compound on inhibition of thrombosis.Methods: The rat thrombosis nodel was induced by electric stimulation.The influences of Radix Notoginseng Compound on thrombus formation and hemorheological parameters were investigated.The rat model of blood stasis was established by combined application of epinephrine with ice bath.The influences of the compound on thrombixin A_2 and prostaglandin I_2 were observed for the model.Results: Compared with the... |
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| Keywords: | Radix Notoginseng thrombus hemorhelogy TXA_2 PGI_2 |
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