Lafutidine can improve the quality of gastric ulcer healing in humans: a randomized, controlled, multicenter trial |
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| Authors: | K Higuchi T Watanabe K Tominaga M Shiba K Nakagawa H Uno K Kitada H Satoh S Chono N Oshitani Y Fujiwara T Arakawa |
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| Institution: | (1) Department of Gastroenterology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan;(2) Department of Gastroenterology, Morimoto Hospital, Osaka, Japan;(3) Department of Gastroenterology, Oono Memorial Hospital, Osaka, Japan;(4) Department of Medicine, Aioi Hospital, Osaka, Japan;(5) Department of Medicine, Fujiidera Municipal Hospital, Fujiidera, Japan;(6) Department of Medicine, Machida Gastrointestinal Hospital, Osaka, Japan |
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| Abstract: | Improving the quality of ulcer healing (QOUH) is one of the valid methods of prevention of relapse of gastric ulcers. We investigated
the effect of lafutidine on the QOUH of gastric ulcer compared with famotidine in a randomized, multi-centre controlled trial.
Consecutive 80 patients with a gastric ulcer were randomly assigned to receive twice daily either lafutidine (10 mg) or famotidine
(20 mg) for 12 weeks. Esophagogastroduodenoscopy was performed to examine the ulcer healing rate and rate of fl at type ulcer
scars using dye-contrast. The gastric ulcer healing rate was 92.1% in the lafutidine group (35/38) and 94.7% in the famotidine
group (36/38). The rate of flat-type ulcer scars was significantly higher in the lafutidine group (68.4%, 26/38) than in the
famotidine group (42.1%, 16/38) (P = 0.021). In conclusion, the present study demonstrated that lafutidine, as compared to
famotidine, yields a signifi cantly superior QOUH in patients with gastric ulcers in the clinical setting.
Received and accepted 3 August 2006 |
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| Keywords: | Gastric ulcer Quality of ulcer healing Lafutidine Famotidine |
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