| 脑梗死患者颈动脉粥样硬化性斑块与hs-CRP、Apo-B、ox-LDL、MMP-9的相关性研究 |
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| 作者单位： | ;1.攀枝花市中心医院药剂科 |
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| 摘 要： | 目的:分析动脉粥样硬化性脑梗死(atherosclerotic cerebral infarction, ASCI)患者血清超敏C反应蛋白(hypersensitive c-reactive protein, hs-CRP)、载脂蛋白-B(apolipoprotein-B, Apo-B)、氧化低密度脂蛋白(oxidized low-density lipoprotein, ox-LDL)及基质金属蛋白酶-9(matrix metalloproteinase-9, MMP-9)水平与颈动脉粥样硬化性斑块(carotid atherosclerotic plaques, CAP)形成的相关性。方法:选取本院神经内科确诊的125例ASCI患者为观察组,另同期选取125例健康者为对照组。比较两组血清hs-CRP、Apo-B、ox-LDL及MMP-9水平,并对病例组行颈动脉超声检查,分析血清hs-CRP、Apo-B、ox-LDL及MMP-9水平与ASCI患者CAP形成的相关性。结果:与对照组相比较,观察组血清hs-CRP、Apo-B、ox-LDL及MMP-9水平显著升高(P<0.01)。观察组中伴CAP形成的患者血清hs-CRP、Apo-B、ox-LDL及MMP-9水平比无CAP形成的患者显著升高(P<0.01)。经多因素Logistic回归分析结果显示,血清hs-CRP(OR=4.76, 95%CI:2.35～9.18)、Apo-B(OR=3.16, 95%CI:1.59～7.32)、ox-LDL(OR=1.48, 95%CI:1.15～2.01)及MMP-9(OR=3.86, 95%CI:1.63～9.14)水平是ASCI患者CAP形成的独立危险因素(P<0.05)。结论:血清hs-CRP、Apo-B、ox-LDL及MMP-9的水平可反映ASCI患者CAP的炎症程度以及斑块的不稳定程度;ASCI患者血清hs-CRP、Apo-B、ox-LDL及MMP-9水平显著升高,其与ASCI患者CAP的形成密切相关,可作为临床诊断ASCI及CAP形成的重要血清学生物标志物。
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| 关 键 词： | 脑梗死 颈动脉粥样硬化性斑块 超敏C反应蛋白 载脂蛋白-B 氧化低密度脂蛋白 基质金属蛋白酶-9 |
Analysis of correlation between carotid atherosclerotic plaques and serum hs-CRP,Apo-B,ox-LDL and MMP-9 levels in patients with atherosclerotic cerebral infarction |
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| Institution: | Panzhihua central hospital, Sichuan panzhihua 617067, China;Panzhihua central hospital, Sichuan panzhihua 617067, China;Panzhihua central hospital, Sichuan panzhihua 617067, China;Panzhihua central hospital, Sichuan panzhihua 617067, China;Panzhihua central hospital, Sichuan panzhihua 617067, China;Panzhihua central hospital, Sichuan panzhihua 617067, China;Panzhihua central hospital, Sichuan panzhihua 617067, China;Panzhihua central hospital, Sichuan panzhihua 617067, China;Panzhihua central hospital, Sichuan panzhihua 617067, China |
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