| 超声心动图观察雄激素替代治疗改善慢性心力衰竭雄性大鼠左室收缩功能 |
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| 引用本文： | 刘静华,邓又斌,杨好意,毕小军,张清阳,常青,黎春雷,周强. 超声心动图观察雄激素替代治疗改善慢性心力衰竭雄性大鼠左室收缩功能[J]. 中国医学影像技术, 2005, 21(2): 173-175 |
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| 作者姓名： | 刘静华 邓又斌 杨好意 毕小军 张清阳 常青 黎春雷 周强 |
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| 作者单位： | 1. 华中科技大学同济医学院附属同济医院超声影像科,湖北,武汉,430030
2. 华中科技大学同济医学院附属同济医院心内科,湖北,武汉,430030 |
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| 摘 要： | 目的自身对照研究雄激素替代治疗前后大鼠的心功能状况.方法二维超声结合定量组织速度成像(QT-VI)技术检测四种不同处理(对照组、阿霉素组、睾丸切除 阿霉素组和睾丸切除 阿霉素 雄激素组)大鼠的心脏,测量常用心功能参数,脱机分析后室间隔和左室侧壁二尖瓣环处的速度曲线,记录收缩期峰值速度Vs.结果睾丸切除 阿霉素 雄激素组左室短轴缩短率和二尖瓣环平均峰值速度比睾丸切除 阿霉素组增高,差异有显著性意义.结论雄激素补充治疗能够改善激素水平低下的充血性心力衰竭大鼠的左室收缩功能.定量组织速度成像技术是评价大鼠心血管疾病模型心功能的一个新方法.
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| 关 键 词： | 睾酮 定量组织速度成像 心室功能,左 动物,实验 |
| 文章编号： | 1003-3289(2005)02-0173-03 |
| 收稿时间： | 2004-11-04 |
| 修稿时间： | 2004-11-04 |
Effects of testosterone on left ventricular systolic function in rats with chronic heart failure |
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| LIU Jing-hu,DENG You-bin,YANG Hao-yi,BI Xiao-jun,ZHANG Qing-yang,CHANG Qing,LI Chun-lei and ZHOU Qiang. Effects of testosterone on left ventricular systolic function in rats with chronic heart failure[J]. Chinese Journal of Medical Imaging Technology, 2005, 21(2): 173-175 |
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| Authors: | LIU Jing-hu DENG You-bin YANG Hao-yi BI Xiao-jun ZHANG Qing-yang CHANG Qing LI Chun-lei ZHOU Qiang |
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| Affiliation: | Department of Medical Ultrasound,Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;Department of Medical Ultrasound,Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;Department of Medical Ultrasound,Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;Department of Medical Ultrasound,Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;Department of Medical Ultrasound,Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;Department of Medical Ultrasound,Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;Department of Medical Ultrasound,Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China |
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| Abstract: | Objective To study the left ventricular systolic function in rats with chronic heart failure before and after administration. Methods Twelve control rats, 20 rats with chronic heart failure, 20 orchiectomy rats admitted with adriamycin and 20 orchiectomy (ORX+AR) rats admitted with adriamycin and testosterone (ORX+AR+T) were involved in the study. The left ventricular diameter (LV), the left ventricular end diastolic volume (EDV), fractional shortening (FS) were measured through M mode echocardiography. The longitudinal systolic velocity (Vs) of the two points at the mitral annulus (posteroseptal and lateral wall) was measured by QTVI. Results The LV and EDV of AR and AR+ORX groups were higher than those of the control group ( P <0.05). The FS and Vs were significantly different between ORX+AR rats and ORX+AR+T rats ( P <0.05). Conclusion Testosterone could improve left ventricular systolic function in rats with CHF which testosterone was decreased. QTVI is a new method to assess cardiac function in rats. |
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| Keywords: | Testosterone Quantitative tissue velocity imaging Ventricular function left Animals loboratory |
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