冠心病病人血清IMA、SICAM-1与hs-CRP的变化

目的探讨冠心病(CHD)病人缺血修饰蛋白(I MA)、可溶性细胞间黏附分子-1(SICAM-1)及超敏C反应蛋白(hs-CRP)的变化及意义。方法选取急性心肌梗死(AMI)病人、不稳定型心绞痛(UAP)病人、稳定型心绞痛(SAP)病人各20例,测定其血清I MA、SICAM-1及hs-CRP的含量,并与20例健康查体者(对照组)进行比较。结果 AMI病人血清I MA、SICAM-1及hs-CRP水平均高于UAP病人、SAP病人和对照组(F=76.52、29.75、12.90,q=6.08～59.02,P<0.01);UAP病人血清I MA、SICAM-1及hs-CRP水平显著高于SAP病人和对照组(q=4.30～181.90,P<0.01);SAP病人血清I MA、SICAM-1及hs-CRP水平与对照组比较,差异亦有显著性(q=2.82～8.58,P<0.01)。不同类型的CHD病人血清I MA、SICAM-1及hs-CRP水平均呈显著正相关(r=0.537～0.699,P<0.01)。结论血清I MA、SICAM-1及hs-CRP水平变化与CHD的发生发展有关。

THE CHANGES AND CLINICAL SIGNIFICANCE OF SERUM ISCHEMIA MODIFIED ALBUMIN, SOLUBLE INTERCELLULAR ADHESION MOLECULE 1 AND C-REACTIVE PROTEIN IN PATIENTS WITH CORONARY HEART DISEASE

Objective To explore the changes of ischemia modified albumin(IMA),soluble intercellular adhesion molecule-1(SICAM-1) and hypersensitive C-reactive protein(hs-CRP) in serum of patients with coronary heart disease(CHD) and their clinical significance. Methods Serum IMA,SICAM-1 and hs-CRP in patients with acute myocardial infarction(AMI),unstable angina pectoris(UAP),and stable angina pectoris(SAP) were detected in the above three groups with 20 patients in each group,the results were compared with that of the health subjects(control group). Results Serum levels of IMA,SICAM-1 and hs-CRP in AMI patients were higher than that in UAP,SAP and control group(F=76.52,29.75,12.90;q=6.08-59.02;P<0.01);Serum IMA,SICAM-1 and hs-CRP in UAP patients were higher than that in SAP and control group(q=4.30-181.90,P<0.01);Serum levels of IMA,SICAM-1 and hs-CRP between SAP and control group were significantly different(q=4.97,8.58,2.82;P<0.01).The serum IMA,SICAM-1 and hs-CRP in different type of CHD patients showed a positive correlation with each other(r=0.537-0.699,P<0.01). Conclusion The changes of serum levels of IMA,SICAM-1 and hs-CRP are associated with the development and progress of coronary heart disease.