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| Survivin在人胃腺癌中的表达及其与临床病理的关系 | |
| 引用本文： | 王莉,王如文,蒋耀光,尹芳,秦叔逵,龚泰乾,赵云平,谭群友,郭伟,范小青.Survivin在人胃腺癌中的表达及其与临床病理的关系[J].现代肿瘤医学,2011,19(8):1591-1594. |
| 作者姓名： | 王莉 王如文 蒋耀光 尹芳 秦叔逵 龚泰乾 赵云平 谭群友 郭伟 范小青 |
| 作者单位： | 1. 第三军医大学大坪医院野战外科研究所,全军胸外中心,重庆,400042 2. 第四军医大学西京医院消化病院,肿瘤生物国家重点实验室,陕西,西安,710032 3. 中国人民解放军八一医院,全军肿瘤中心内科,江苏,南京,210002 |
| 基金项目： | 中国博士后科学基金，国家自然科学基金 |
| 摘 要： | 目的:研究Survivin蛋白在人胃腺癌细胞系和组织中的表达及其临床意义。方法:用RT-PCR、Western Blot方法及免疫组织化学方法检测6株人胃腺癌细胞系,80例人胃腺癌及癌旁组织中Survivin基因的表达。结果:Survivin在6株人胃腺癌细胞系均有表达,胃腺癌组织中Survivin表达阳性率为60%,癌旁正常胃组织均无Survivin的表达;在胃腺癌中的表达与患者生存期和肿瘤的区域淋巴结转移(P<0.05)密切相关,与肿瘤分化程度无相关性(P>0.05)。结论:Survivin的变化与胃腺癌的发生和预后密切相关,并可能成为一个有希望的肿瘤治疗靶点。 |
| 关 键 词： | Survivin基因 人胃腺癌 RT-PCR 免疫组织化学 |
Expression of Survivin and its clinical significance in human gastric adenocarcinoma |
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| WANG Li,WANG Ru-wen,JIANG Yaoguang,YIN Fang,QIN Shukui,GONG Taiqian,ZHAO Yunping,TAN Qunyou,GUO Wei,FAN Xiaoqing.Expression of Survivin and its clinical significance in human gastric adenocarcinoma[J].Journal of Modern Oncology,2011,19(8):1591-1594. | |
| Authors: | WANG Li WANG Ru-wen JIANG Yaoguang YIN Fang QIN Shukui GONG Taiqian ZHAO Yunping TAN Qunyou GUO Wei FAN Xiaoqing |
| Institution: | WANG Li1,WANG Ru-wen1,JIANG Yaoguang1,YIN Fang2,QIN Shukui3,GONG Taiqian1,ZHAO Yunping1,TAN Qunyou1,GUO Wei1,FAN Xiaoqing11Thoracic Surgery Department,Institute of Surgery Research,Daping Hospital,Third Military Medical University,Chongqing 400042,China,2State Key Laboratory of Cancer Biology & Xijing Hospital of Digestive Diseases,Fourth Military Medical University,Xi'an,Shaanxi Province 710032,3Tumor Center,PLA.No.81 Hospital,Nanjing 210002,Jiangsu Province |
| Abstract: | Objective:To investigate the expression of Survivin in human gastric adenocarcinoma and analyze its relationship with clinicopathological parameters.Methods: The expression of Survivin expression was assessed using RT-PCR and western blot and immunohistochemistry(IHC) in 6 human gastric adenocarcinoma cell lines and 80 human gastric adenocarcinoma tissues and their corresponding normal tissues.The relationship between Survivin expression and the clinicopathological factors was analyzed.Results: Survivin was... |
| Keywords: | RT-PCR |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |