| 急性髓细胞白血病预后相关分子遗传学研究的最新进展 |
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| 引用本文： | 邱林,马军.急性髓细胞白血病预后相关分子遗传学研究的最新进展[J].实用医院临床杂志,2011,8(4):4-6. |
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| 作者姓名： | 邱林 马军 |
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| 作者单位： | 黑龙江省哈尔滨血液病肿瘤研究所,黑龙江,哈尔滨,150010 |
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| 摘 要： | 新一代高通量基因组学技术在急性髓细胞白血病(acute myelocytic leukemia,AML)的应用,为AML分子遗传学的研究提供了崭新的平台。随着AML相关突变和异常表达基因的发现,我们对AML的异质性和预后分级有了新的认识,也必将为AML分子靶向治疗和个体化治疗提供强有力依据。
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| 关 键 词： | 急性髓细胞白血病 预后 分子遗传学 基因突变 |
New progress of prognosis-related molecular genetics of adult acute myeloid leukemia |
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| QIU Lin,MA Jun.New progress of prognosis-related molecular genetics of adult acute myeloid leukemia[J].Practical Journal of Clinical Medicine,2011,8(4):4-6. |
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| Authors: | QIU Lin MA Jun |
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| Institution: | QIU Lin,MA Jun(Harbin Institute of Hematology and Oncology,Harbin 150010,China) |
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| Abstract: | The application of next-generation high throughout genomics techniques in acute myeloid leukemia provides a new platform for study of molecular genetics of acute myelocytic leukemia(AML).We have deeper knowledge for the heterogeneity and prognostic stratification of AML,with the discovery of new AML-related gene mutations and aberrant gene expressions which also would provide powerful evidences for molecular targeting therapy and individualized therapy of AML. |
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| Keywords: | Acute myelocytic leukemia Prognosis Molecular genetics Gene mutation |
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