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| 芹菜素对人结肠癌细胞株SW480体外侵袭能力的抑制作用 | |
| 引用本文： | 孟勇,李华,马清涌,林增海,吴华涛. 芹菜素对人结肠癌细胞株SW480体外侵袭能力的抑制作用[J]. 现代肿瘤医学, 2011, 19(8): 1522-1524. DOI: 10.3969/j.issn.1672-4992.2011.08.14 |
| 作者姓名： | 孟勇 李华 马清涌 林增海 吴华涛 |
| 作者单位： | 1. 汕头大学医学院第一附属医院普外科,广东,汕头,515041 2. 西安交通大学第二附属医院普外科,陕西,西安,710000 3. 西安交通大学第一附属医院肝胆外科,陕西,西安,710061 |
| 基金项目： | 广东省科技计划项目，广东省中医药局科研课题，汕头市重点科技计划项目 |
| 摘 要： | 目的:观测芹菜素对大肠癌细胞株SW480体外侵袭、粘附和运动能力的影响。方法:人工重组基底膜技术观察药物对细胞侵袭、运动和粘附的影响。结果:芹菜素处理后SW480细胞的侵袭、运动及粘附能力下降,并呈时间和剂量依赖性。结论:芹菜素多个层面抑制SW480细胞的侵袭、运动和粘附。 |
| 关 键 词： | 芹菜素 结肠肿瘤 侵袭 粘附 |
Inhibitory effect of apigenin on the invasive ability of the colon cancer cell SW480 in vitro |
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| MENG Yong,LI Hua,MA Qingyong,LIN Zenghai,WU Huatao. Inhibitory effect of apigenin on the invasive ability of the colon cancer cell SW480 in vitro[J]. Journal of Modern Oncology, 2011, 19(8): 1522-1524. DOI: 10.3969/j.issn.1672-4992.2011.08.14 | |
| Authors: | MENG Yong LI Hua MA Qingyong LIN Zenghai WU Huatao |
| Affiliation: | MENG Yong1,LI Hua2,MA Qingyong3,LIN Zenghai1,WU Huatao1 1Department of General Surgery,First Affiliated Hospital of Shantou University Medical College,Guangdong Shantou 515041,China,2Department of General Surgery,Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710000,3Department of Hepatobiliary Surgery,First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061 |
| Abstract: | Objective:To explore the effects of apigenin on invasion,metastasis and adhesion in human SW480 cell.Methods: Matrigel basement membrane matrix was used to investigate the effects of apigenin on invasion,metastasis and adhesion in human SW480 cell.Results: After treated by apigenin,the ability of invasion,metastasis and adhesion descended with dose and time dependent.Conclusion: Apigenin could inhibit the ability of invasion,metastasis and adhesion.It could inhibit many key points in the invasive and metast... |
| Keywords: | apigenin colon carcinoma invasion adhesion |
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