MoCA在脑小血管病病人认知功能障碍筛查中作用

目的 研究蒙特利尔认知量表(MoCA)在脑小血管病(SVD)病人认知功能障碍评估中的意义.方法 将103例SVD病人分为认知功能正常组和认知功能障碍组,应用MoCA量表及简易精神状态量表(MMSE)进行认知功能评估.结果 认知功能障碍组MoCA总分为(18.08±3.16)分,MMSE总分为(25.53±2.91)分,...

VALUE OF THE MONTREAL COGNITIVE ASSESSMENT IN DETECTION OF COGNITIVE IMPAIRMENT IN PATIENTS WITH CEREBRAL SMALL VESSEL DISEASE

Objective To study the validity of Montreal Cognitive Assessment(MoCA) in the detection of cognitive impairment in patients with cerebral small vessel disease(SVD). Methods This study consisted of 103 SVD patients,who were divided into cognitive dysfunction group and cognitive normal group.Cognitive appraisal was conducted using MoCA and MMSE.Results Of cognitive dysfunction group,the total scores of MoCA and MMSE were 18.08±3.16 and 25.53±2.91,respectively,the two scores being correlated(r=0.522,P<0.05).Compared with the cognitive normal group,the scores of MoCA and MMSE in dysfunction group were lower,the differences of subitems and total scores between the two groups were significant,except that one item "attention" in MoCA(t=3.53-12.22,P<0.05),and of MMSE,only total score,memory and recall were significant difference between the two groups(t=2.00-3.67,P<0.05).The best cutoff value of MoCA was 22/23,with a sensitivity of91.9% and a specificity of 95.1% in the identification of cognitive dysfunction in patients with SVD according to the ROC curveanalysis. Conclusion MoCA provides higher sensitivity and specificity than MMSE in screening cognitive dysfunction in SVD patients,with its optimal cutoff value of 22/23.