改良电痉挛治疗与686项目结合治疗精神分裂症阳性症状

目的探讨改良电痉挛治疗(MECT)与686项目结合治疗精神分裂症阳性症状的临床疗效。方法将299例686项目精神分裂症患者随机分为两组,分别给予MECT与利培酮治疗8周。采用简明精神病评定量表(BPRS)、阳性症状量表(SAPS)、不良反应量表(TESS)评定疗效及不良反应。结果实验组治疗总有效率为91.33%,利培酮组为62.41%,两组比较差异有统计学意义(χ2=4.62,P0.05)。实验组的锥体外系反应、窦速和停经泌乳等不良反应低于对照组(χ2=9.50,6.91,4.95;P0.05)。结论 MECT与686项目结合治疗精神分裂症阳性症状安全有效。

Integrated Therapy with Modified Electric Convulsive Therapy and 686 Project for Positive Symptoms of Schizophrenia

Objective To explore the clinical effect of therapy of MECT and 686 project for schizophrenia. Methods A total of 299 schizophrenia patients of 686 project randomly divided into two groups were given a treatment of MECT and Risperidone for 8 weeks. The brief psychiatric rating scale（BPRS） , the positive syndrome scale（SAPS） and the Treatment Emergent Sympteol Scale（TESS） were used to evaluate the efficacy and adverse reaction. Results The total effectiveness of the study group was 91.33% ,while the control group 62.41%. The comparison difference of the two groups was statistically significant （ X2 = 4.62, P 〈 0.05 ）. Team of extrapyramidal reactions, sinus tachycardia and amenorrhea lactation syndrome adverse reaction were lower than the control group （X2 = 9.50,6.91,4.95 ;P 〈 0.05 ）. Conclusion The combined therapy of MECT and 686 project is safe and effective for positive symptoms of schizophrenia.