舌下含服粉尘螨滴剂治疗儿童变应性鼻炎合并腺样体肥大的疗效观察

目的：探讨舌下特异性免疫治疗对儿童变应性鼻炎及腺样体肥大的治疗效果。方法将诊断为变应性鼻炎合并腺样体肥大的92例患儿随机分为两组，研究组应用舌下含服粉尘螨滴剂治疗，对照组采用常规抗过敏药物治疗，研究组观察3、6个月，对照组观察3个月，采用VAS评分记录患者鼻过敏和睡眠打鼾症状的变化，采用鼻内镜检查及鼻咽侧位片A/N比检测患儿腺样体大小的改变。结果①两组患者治疗后鼻过敏症状、睡眠打鼾症状VAS评分均低于治疗前；②常规抗过敏药物治疗组睡眠打鼾症状VAS评分低于舌下含服组，差异均有显著性统计学意义；③两组治疗后腺样体A/N比率均小于治疗前，且常规抗过敏药物治疗组小于舌下含服组（P＜0．05）。结论舌下特异性免疫治疗可有效控制儿童变应性鼻炎合并腺样体肥大患儿的过敏症状、睡眠打鼾症状及腺样体大小，可作为非手术干预治疗变应性鼻炎伴腺样体肥大的有效方法。

Efficacy of specific sublingual immunotherapy with dermatophagoides farinae drops on allergic rhinitis and ade-noid hypertrophy in children

Objective To explore the relationship between allergic rhinitis and the pathogenes of adenoid hypertrophy in children, and to explore the specific sublingual immunotherapy effect on both diseases.Methods 92 cases of allergic rhinitis with adenoid hypertrophy were involved in the study, which were divided into two groups accepting dermatopha-goides farinae drops specific sublingual immunotherapy （ the research group） or routine treatment of anti-allergic drug （ the control group） , respectively.After 3 and 6 months of treatment in the research group and 3 months in the control group, nasal allergies, sleep snoring and changes of adenoid were observed and applied to evaluate the treatment effect. Results 1.After treatment, VAS scores of nasal allergies and sleep snoring in the two groups were lower than those before the treatment, and sleep snoring VAS score of the control group was lower than that of the research group （ P〈0.05）.2.The adenoid A/N ratios of the two groups after treatment was lower than those before the treatment, and that of the control group was less than that of the research group （P〈0.05）.Conclusion There is a close relationship be-tween allergic rhinitis and adenoid hypertrophy in children.Specific sublingual immunotherapy could improve the nasal allergy symptoms, at the same time, sleep snoring improved as a result of reducing the adenoid volume, provides a new method for non-surgical treating allergic rhinitis with adenoid hypertrophy.