|
|||||
|
|
| N-乙酰半胱氨酸对烟雾吸入性肺损伤氧化应激的影响 | |
| 引用本文： | 傅祖红,杨宗城,刘理,刘志远,何保斌,刘志遐,吴江平. N-乙酰半胱氨酸对烟雾吸入性肺损伤氧化应激的影响[J]. 中华烧伤杂志, 2002, 18(3): 152-154 |
| 作者姓名： | 傅祖红 杨宗城 刘理 刘志远 何保斌 刘志遐 吴江平 |
| 作者单位： | 1. 广州军区武汉总医院呼吸科,430070 2. 400038,重庆,第三军医大学西南医院全军烧伤研究所 3. 广州军区武汉总医院呼吸科 |
| 摘 要： | 目的 研究N -乙酰半胱氨酸 (NAC)对烟雾吸入性肺损伤氧化应激及抗氧化能力的影响。 方法 采用烟雾吸入性肺损伤大鼠模型 ,检测吸入伤后肺泡灌洗液 (BALF)中白细胞数(WBC)、肺组织髓过氧化物酶 (MPO)活性、过氧化氢 (H2 O2 )含量、谷胱甘肽 (GSH)含量及总抗氧化能力(TAO)。 结果 NAC治疗可显著降低吸入伤后BALF中WBC数 ,降低肺组织MPO活性及H2 O2 含量 ,并显著提高肺组织GSH含量及TAO水平。 结论 NAC治疗可减轻吸入伤后肺脏氧化应激程度 ,提高肺脏抗氧化应激能力 |
| 关 键 词： | 烟雾吸入损伤 乙酰半胱氨酸 氧化性应激 |
| 修稿时间： | 2000-08-25 |
The influence of N-acetyl-L-cysteine on pulmonary injury and oxygen stress after smoke inhalation injury |
|
| FU Zuhong,YANG Zongcheng,LIU Li,LIU Zhiyuan,HE Baobin,LIU Zhixia,WU Jiangping. The influence of N-acetyl-L-cysteine on pulmonary injury and oxygen stress after smoke inhalation injury[J]. Chinese journal of burns, 2002, 18(3): 152-154 | |
| Authors: | FU Zuhong YANG Zongcheng LIU Li LIU Zhiyuan HE Baobin LIU Zhixia WU Jiangping |
| Affiliation: | Institute of Burn Research, Southwestern Hospital, The Third Military Medical University, Chongqing 400038, P.R. China. |
| Abstract: | Objective To investigate the influence of N-acetyl-L-cysteine (NAC) on pulmonary injury and oxygen stress caused by smoke inhalation injury. Methods Rats inflicted with smoke inhalation injury were employed as the model.WBC in BALF(bronchoalveolar lavage fluid),MPO (myeloperoxidase) activity,hydrogen peroxide(H 2O 2) content,GSH(glutathione) content and total antioxidant (TAO) capacity in pulmonary tissue were determined. Results Postinjury WBC in BALF,MPO activity in pulmonary tissue and H 2O 2 content decreased obviously after NAC treatment.But the pulmonary tissue contents of GSH and ATO increased evidently after the treatment with NAC. Conclusion NAC treatment could ameliorate pulmonary oxygen stress after smoke inhalation injury.As a result,the pulmonary antioxidant capacity was improved. |
| Keywords: | Smoke inhalation injury N-acetyl-L-cysteine (NAC) Oxygen stress |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |