A facile synthesis of alpha,alpha'-(EE)-bis(benzylidene)-cycloalkanones and their antitubercular evaluations |
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Authors: | Singh Nimisha Pandey Jyoti Yadav Amit Chaturvedi Vinita Bhatnagar Shalini Gaikwad Anil N Sinha Sudhir Kumar Kumar Awaneet Shukla P K Tripathi Rama P |
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Affiliation: | Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226001, India. |
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Abstract: | An economical and facile synthesis of alpha,alpha'-(EE)-bis(benzylidene)-cycloalkanones was achieved by the reaction of cycloalkanones with different aromatic aldehydes using ethanolic KOH in good yields. Few of the selected compounds were reduced with NaBH(4) to the respective alpha,alpha'-(EE)-bis(benzylidene)-cycloalkanols. All these compounds and our earlier synthesized cyclohexyl phenyl methanols were evaluated for their antitubercular, antifungal and antibacterial activities. Several compounds displayed moderate antitubercular activity with MIC=12.5-1.56 microg/mL. However, none of the compounds displayed any significant antifungal activity. |
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