| ClC-3氯通道研究进展 |
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| 引用本文： | 张海宁,关永源. ClC-3氯通道研究进展[J]. 中国药理学通报, 2003, 19(2): 125-129 |
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| 作者姓名： | 张海宁 关永源 |
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| 作者单位： | 中山大学中山医学院药理学教研室,广州,510080 |
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| 基金项目： | 国家自然科学基金资助课题 (No 39970 849)，广东省自然科学基金团队项目CMB (No 0 0 730 )，国家科技部攀登计划 (国科基字[1999] 0 45 )资助项目 |
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| 摘 要： | 容积敏感性氯通道普遍存在于哺乳动物细胞 ,对维持细胞容积平衡、调节细胞电活动等多种生理功能发挥重要作用。ClC 3作为可能编码ICl.swell的基因 ,受到广泛关注。本文就近年来对ClC 3氯通道在通道特点、生理作用及有关的通道调节机制等方面的研究进行了综述
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| 关 键 词： | ClC-3 氯通道 组织分布 ICl.swell |
| 文章编号： | 1001-1978(2003)02-0125-05 |
| 修稿时间： | 2002-05-08 |
Progress in the study of ClC-3 chloride channel |
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| ZHANG Hai-Ning,GUAN Yong-Yuan. Progress in the study of ClC-3 chloride channel[J]. Chinese Pharmacological Bulletin, 2003, 19(2): 125-129 |
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| Authors: | ZHANG Hai-Ning GUAN Yong-Yuan |
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| Abstract: | Volume-sensitive chloride channels are now known to be ubiquitously present in mammalian cells. They are required for the regulation of cell volume, electrical activity and so on. ClC-3 is studied as a most likely candidate to encode a volume-sensitive chloride channels in the hands of several groups. The review is supposed to provide a broad overview of progress in the recent years, including the characterization of the channel, their presumed physiological roles, the regulation mechanism of ClC-3 chloride channel, etc. |
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| Keywords: | ClC-3 chloride channel tissue distribution I Cl.swell |
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