被动吸烟对小鼠白介素-6、白介素-8水平表达的影响

目的观察被动吸烟对小鼠白介素石（IL-6）、白介素-8（IL-8）水平表达的影响。方法将小鼠随机分为2组，分别为实验组和对照组。用ELISA方法检测小鼠血清中IL-6、IL-8的表达情况。结果实验组小鼠血清中IL-6含量为（41．77±1．87）pg／ml，对照组小鼠血清中IL-6含量为（34．98±1．84）pg／ml，两者相比，差异有统计学意义（t=14．15，P〈0．01）。实验组小鼠血清中IL-6含量增高；实验组小鼠血清中IL-8含量为（52．95±1．09）pg／ml，对照组小鼠血清IL-8含量为（65．63±2．59）pg／ml，两者相比差异有统计学意义（t=24．86，P〈0．01）。实验组小鼠血清中IL-8含量减少。结论被动吸烟能促使小鼠IL-6的表达升高，IL-8的表达降低。可能与其参与炎症反应过程有关。

Effect of Passive Smoking on the Expression of Serum IL6 and IL8 in Mice

Objective] To observe the effect of passive smoking on the expression of serum IL6 and IL8 in mice. Methods ] The mice were stochastically divided into two groups, namely, the experiment group and the control ; the expression of serum IL6 and IL8 were detected with ELISA. Results] The content of serum IL6 in the experiment group and the control were （ 41.77 ± 1.87 ） pg/ml and 34.98 ± 1.84 ） pg/ml respectively, the difference was significant （ t = 14.15, P 〈 0.01 } ; the expression of serum IL6 increased in the experiment group ; the content of serum IL8 in the two groups were （ 52.95 ±1.09 ） pg/ml and { 65.63 ± 2.59 ） pg/ml respectively, the difference was significant （ t =24.86, P 〈0.01 ）, the content of serum IL8 decreased in the experiment group. Conclusion] Passive smoking can lead to the increase of IL6 and decrease of IL8 in mice, which might be related with the inflammation reaction.